334632-65-4

Upstream product

• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 20054-45-9 N-methyl-2-sulfanylbenzamide 
• 593-51-1 methylamine hydrochloride 
• 865168-52-1 2-(4-bromo-2-nitro-phenylsulfanyl)-benzoyl chloride 
• 33441-56-4 ethyl 2-mercaptobenzoate 
• 544710-44-3 2-[(4-bromo-2-nitrophenyl)thio]benzoic acid 

Downstream Products

• 334632-67-6 N-methyl-2-(2-amino-4-bromophenylthio)benzylamine 
• 334632-69-8 N-methyl-2-(2-amino-4-iodophenylthio)benzylamine 
• 334632-66-5 N-methyl-2-(4'-bromo-2'-nitrophenylthio)benzylamine 
• 411208-44-1 N-(2-fluoroethyl)-N-methyl-2-(4'-bromo-2'-nitrophenylthio)benzylamine 

Relevant academic research and scientific papers

Precursor synthesis and radiolabelling of [11C]ADAM: a potential radioligand for the serortonin transporter exploration by pet

The serotoninergic system is involved in a variety of neurological and psychiatric disorders. Exploration of the serotonin transporters (5-HTT) in living human brain by PET would be of great value for better understanding, diagnosis and therapeutic follow up of these diseases. In order to obtain a selective raddioligand to explore the 5-HTT by PET we report the synthesis of [11C]N,N-dimethyl-2-(2-amino-4-iodophenylthio)-benzylamine ([11C]ADAM. The precursor for labelling N-demethyl ADAM, was obtained in five steps using 2,5-dibromonitrobenzene and 2-thio-N-methylbenzamide as starting material. [11C]ADAM was synthesised by N-alkylation of the precursor using [11C]methyl iodide in DMF. The incorporation yield of [11C]methyl iodide was in the range of 50 to 70 percent. Finally [11C]ADAM was obtained in 30 minutes synthesis time including HPLC and with a radiochemical purity better than 99 percent.