20056-96-6Relevant academic research and scientific papers
Organocatalytic aza-Michael Reaction to 3-Vinyl-1,2,4-triazines as a Valuable Bifunctional Platform
Buttard, Floris,Hiebel, Marie-Aude,Suzenet, Franck,Berthonneau, Clément,Brière, Jean-Fran?ois
, p. 3702 - 3714 (2019)
An unprecedented catalytic aza-Michael addition to substituted 3-vinyl-1,2,4-triazines, as original bifunctional platforms for the domino conjugate addition inverse-electron-demand hetero-Diels-Alder/retro-Diels-Alder (ihDA/rDA) reaction, was achieved using the highly acidic triflimide as an organocatalyst. Based on the use of alkoxyamine nucleophiles, this sequence not only highlights a rare example of the catalytic aza-Michael reaction to alkenylazaarenes but also proves to be useful for the elaboration of an array of biorelevant tetrahydro-[1,6]-naphthyridines.
Polarity-mismatched addition of electrophilic carbon radicals to an electron-deficient acceptor: Cascade radical addition-cyclization-trapping reaction
Yoshioka, Eito,Kohtani, Shigeru,Sawai, Kaori,Kentefu,Tanaka, Eri,Miyabe, Hideto
, p. 8588 - 8604,17 (2020/09/15)
The polarity-mismatched perfluoroalkyl radical addition to electron-deficient alkenes was studied. For this study, several substrates having two polarity-different radical acceptors were employed to investigate the regiochemical courses of cascade reactio
A dramatic effect of double bond configuration in N-oxy-3-aza Cope rearrangements-a simple synthesis of functionalised allenes
Pinto, Luis F.V.,Glória, Paulo M.C.,Gomes, Mário J.S.,Rzepa, Henry S.,Prabhakar, Sundaresan,Lobo, Ana M.
experimental part, p. 3446 - 3449 (2009/09/25)
The first examples of low temperature N-oxy-3-aza Cope rearrangements, leading to functionalised allenes are described, where the Z-configuration of the enaminic double bond in the rearranging system proves critical.
