200624-30-2

Upstream product

• 177489-17-7 2-chloro-4-fluoro-5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-benzoic acid 
• 177211-21-1 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-4,4,4-trifluoro-1,3-butanedione 
• 142623-96-9 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-5-(trifluoromethyl)-1H-pyrazole 
• 142623-48-1 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole 
• 177211-26-6 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-ethanone 
• 452-73-3 2-chloro-4-fluorotoluene 
• 174514-08-0 5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid 

Relevant academic research and scientific papers

The radiolabeled syntheses of JV 485, a herbicide candidate for winter wheat

JV 485 [14C-Ph] and JV 485 [14C-Py] were synthesized in seven steps in 35% and 44% overall yields, respectively, utilizing the same reaction schemes. The key step in each of the syntheses is a one pot Mid-Century Oxidation (1) of an aromatic methyl group to a carboxylic acid. The 14C radiolabeled syntheses of two isolated metabolites of JV 485 were also completed. Preparation of the JV 485 [phenyl-14C(U)] amide was completed in 62% yield from 2-chloro-5-[4-bromo-1-methyl-5-trifluoromethyl)-1H-pyrazol-3-yl]-4-fluorobenzoic acid [ring-14C(U)], 9. Preparation of the JV 485 [phenyl-14C(U)] desmethyl acid 13 was accomplished in 18% overall yield in four steps from 3-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-5-(trifluoromethyl)-1H-pyrazole, 4.