142623-48-1

Basic information

• Product Name: 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole
• Synonyms: 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole
• CAS NO: 142623-48-1
• Molecular Weight: 292.663
• Mol File: 142623-48-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 44-48°C
• CAS DataBase Reference: 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole(142623-48-1)
• EPA Substance Registry System: 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole(142623-48-1)

Safety Data

• Hazardous Substances Data: 142623-48-1(Hazardous Substances Data)

Usage

Uses

3-(4-Chloro-2-fluoro-5-methylphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.

Upstream product

• 77-78-1 dimethyl sulfate 
• 142623-96-9 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-5-(trifluoromethyl)-1H-pyrazole 
• 1396123-92-4 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole 
• 200190-87-0 3-bromo-6-chloro-4-fluoro-toluene 
• 1067233-79-7 4-trifluoromethyl-N-methylsydnone 
• 200190-84-7 1-chloro-4-ethynyl-5-fluoro-2-methylbenzene 
• 177211-21-1 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-4,4,4-trifluoro-1,3-butanedione 
• 177211-26-6 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-ethanone 
• 452-73-3 2-chloro-4-fluorotoluene 

Downstream Products

• 174514-08-0 5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoic acid 
• 200624-30-2 5-(4-bromo-1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-2-chloro-4-fluoro-benzoyl chloride 
• 177489-17-7 2-chloro-4-fluoro-5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-benzoic acid 

Relevant articles and documents

A general and regioselective synthesis of 5-trifluoromethyl-pyrazoles

Two synthetic approaches to 4-trifluoromethylsydnones, a novel class of these mesoionic reagents, are reported. These compounds undergo regioselective alkyne cycloaddition reactions, thereby providing a general approach to 5-trifluoromethylpyrazoles. This method has been employed in a short formal synthesis of the herbicide fluazolate.

Preparation of substituted 3-aryl-5-haloalkyl-pyrazoles having herbicidal activity

Processes for preparing substituted 3-aryl-5-haloalkyl-pyrazoles and, specifically, for preparing C1-5 alkyl esters of 5-?1-(C1-5 alkyl)-4-halo-5-(C1-3 haloalkyl)-1H-pyrazole-3-yl!-2,4-dihalo-benzoic acids such as isopropyl 5-?4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl!-2-chloro-4-fluorobenzoate, are presented. The described processes include novel approaches for forming phenyl-diketones, forming and alkylating pyrazoles, brominating heterocyclic compounds, oxidizing alkyl-substituted benzene compounds, and esterifying carboxylic acids. These processes may be combined to prepare 3-aryl-5-haloalkyl pyrazoles, or alternatively, used in subcombinations or individually to prepare intermediates or other useful compounds.