200628-11-1

Basic information

• Product Name: dimethyl 1-methyl-1,4-dihydro-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate
• CAS NO: 200628-11-1
• Molecular Weight: 317.342
• Mol File: 200628-11-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: dimethyl 1-methyl-1,4-dihydro-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 1-methyl-1,4-dihydro-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate(200628-11-1)
• EPA Substance Registry System: dimethyl 1-methyl-1,4-dihydro-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate(200628-11-1)

Safety Data

• Hazardous Substances Data: 200628-11-1(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 922-67-8 propynoic acid methyl ester 
• 74-89-5 methylamine 
• 56820-26-9 dimethyl 1,4-dihydro-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate 
• 74-88-4 methyl iodide 

Relevant articles and documents

One-pot synthesis of N-substituted 4-aryl-1,4-dihydropyridines under solvent-free conditions and microwave irradiation

The three-component condensation of benzaldehyde derivatives, alkyl propiolates, and primary amines catalyzed by silica gel, zeolite HY, montmorillonite K-10, and acidic alumina under microwave irradiation gave N-substituted 4-aryl-1,4-dihydropyridines in short reaction times and high yields. The best results were obtained with silica gel.

Novel solid-state synthesis of dimeric 4-aryl-1,4-dihydropyridines

On irradiation in the solid state the 4-aryl-1,4-dihydroypridines 1 undergo [2+2] cycloadditon to centro-symmetric head-to-tail dimers 3 and 4a. The almost exclusive formation of the cage dimers 3 via the C2-symmetric syn-dimers 2 takes place in nearly quantitative yields, in contrast with the cycloaddition reaction of the anti-dimer 4a, which is accomplished by photooxidation to pyridine 5a.