200636-22-2

Usage

Uses

Used in Pharmaceutical Industry:
Propanoic acid, 2,2-dimethyl-, 3-[(1S,2R)-2-hydroxy-3-(phenylmethoxy)-1-[(phenylmethoxymethyl]propoxy]propyl ester is used as an intermediate in the synthesis of pharmaceuticals for its ability to participate in various chemical reactions due to its functional groups. Its unique properties may contribute to the development of new drugs with potential therapeutic effects.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, Propanoic acid, 2,2-diMethyl-,3-[(1S,2R)-2-hydroxy-3-(phenylMethoxy)-1-[(phenylMethoxy)Methyl]propoxy]propyl ester serves as a valuable intermediate for the synthesis of other complex organic compounds. Its functional groups allow for further modification and the creation of new molecules with specific properties and applications.
Used in Drug Development:
Due to its unique structure and potential reactivity, Propanoic acid, 2,2-dimethyl-, 3-[(1S,2R)-2-hydroxy-3-(phenylmethoxy)-1-[(phenylmethoxymethyl]propoxy]propyl ester may have potential applications in drug development. Researchers can explore its interactions with biological targets and evaluate its efficacy in treating various diseases or conditions.

Upstream product

• 80183-15-9 (2R,3R)-1,4-bis(benzyloxy)-2,3-epoxy butane 
• 68973-05-7 (2R*,3S*)-2,3-bis((benzyloxy)methyl)oxirane 
• 3282-30-2 pivaloyl chloride 
• 200636-15-3 (2R,3S)-1,4-dibenzyloxy-3-(3-hydroxypropoxy)butan-2-ol 

Downstream Products

• 239100-37-9 (5Z,7E)-(1R,2R,3R,24R)-1,3,24-tris(tert-butyldimethylsilyloxy)-2-(3-tertbutyldimethylsilyloxypropoxy)-9,10-secocholesta-5,7,10⁽¹⁹⁾-triene 
• 239100-36-8 (5Z,7E)-(1R,2R,3R,24S)-1,3,24-tris(tert-butyldimethylsilyloxy)-2-(3-tertbutyldimethylsilyloxypropoxy)-9,10-secocholesta-5,7,10⁽¹⁹⁾-triene 
• 915160-20-2 (2S,3S)-3-(1,4-bisbenzyloxy-3-hydroxybutan-2-yloxy)propyl pivalate 
• 1006908-55-9 (2S,3R)-3-[(4-nitrobenzoyl)oxy-1,4-bisbenzyloxybutan-2-yloxy]propyl pivalate 

Relevant academic research and scientific papers

Synthesis of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]

A convergent synthesis of biologically interesting 20-epi-eldecalcitol which possesses an inverted C-21 methyl substituent at the 20-position of the side chain of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (eldecalcitol) is described.

Two convergent approaches to the synthesis of 1,25-dihydroxy 2-(3-hydroxypropoxy)vitamin D3 (ED-71) by the lythgoe and thf trost coupling reactions

Two convergent syntheses of 1,25-dihydroxy-2-(3-hydroxypropoxy)vitamin D3 (ED-71) by the Lythgoe coupling reaction between the A-ring phosphine oxide and the C/D-ring ketone and the Trost coupling reaction between the A-ring ene-yne and the C/D-ring bromomethylene are described.

Synthesis and biological characterization of 1α,24,25-trihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (24-hydroxylated ED-71)

24-Hydroxylated derivatives were synthesized in 24(R) and 24(S) forms by the convergent method as analogs related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3. In the convergent synthesis, the A-ring fragment, synthesized from diethyl D-tartarate, and the C/D-ring fragments in 24(R) and 24(S) forms (vitamin D numbering), obtained from vitamin D2 via the Inhoffen-Lythgoe diol, were coupled in moderate yields to give 1α,24(R),25-trihydroxy-2β-(3-hydroxypropoxy)vitamin D3 and 1α,24(S),25-trihydroxy-2β-(3-hydroxypropoxy)vitamin D3. In preliminary biological evaluations, 24-hydroxylation of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 caused weakened affinity to vitamin D binding protein in vitro and less calcemic activity in vivo compared to the parent compound. While the affinity to vitamin D receptor in 24(R) epimer was sustained, the affinity in 24(S) epimer was less than that of the parent compound. Copyright

Convergent synthesis of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)

A convergent and versatile synthesis of the potent vitamin D analog, 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 [1] (ED-71) is described.