20065-99-0

Basic information

• Product Name: Hennadiol
• Synonyms: Hennadiol;29-Hydroxylupeol;30-Hydroxylup-20(29)-en-3beta-ol;3beta,30-Dihydroxylup-20(29)-ene;Lup-20(29)-ene-3beta,30-diol;Wallichenol
• CAS NO: 20065-99-0
• Molecular Formula: C30H52O2
• Molecular Weight: 444.73268
• Mol File: 20065-99-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Hennadiol(CAS DataBase Reference)
• NIST Chemistry Reference: Hennadiol(20065-99-0)
• EPA Substance Registry System: Hennadiol(20065-99-0)

Safety Data

• Hazardous Substances Data: 20065-99-0(Hazardous Substances Data)

Usage

General Description

Hennadiol is a chemical compound belonging to the class of diterpenoids. It is derived from the roots of the plant Salvia officinalis, also known as common sage. Hennadiol has been found to possess antioxidant, anti-inflammatory, and antimicrobial properties. It has also shown potential in inhibiting the growth of cancer cells, particularly in prostate, breast, and colon cancer. Additionally, hennadiol has demonstrated anti-diabetic effects by lowering blood glucose levels and improving insulin sensitivity. These properties make hennadiol a promising candidate for further research and potential use in the development of pharmaceutical and therapeutic applications.

Upstream product

• 1617-68-1 lupeol acetate 
• 20555-16-2 lup-20(30)-en-3β-ol-29-al acetate 
• 555-31-7 aluminum isopropoxide 
• 67-63-0 isopropyl alcohol 
• 545-47-1 lupenol 
• 64181-07-3 3β-hydroxy-lup-20(29)-en-30-al 
• 20066-00-6 30-bromo lupenyl acetate 
• 20065-98-9 3β,30-di-O-acetyllup-20(29)-ene 
• 72944-06-0 30-hydroxylup-20⁽²⁹⁾-en-3-one 

Relevant articles and documents

ISOLATION OF DIHYDROXYLUPENE AND DIHYDROXYLUPANE FROM THE BARK OF LAWSONIA INERMIS

Two pentacyclic triterpenes isolated from the bark of henna were identified as 3β,30-dihydroxylup-20(29)-ene (hennadiol), and (20S)-3β,30-dihydroxylupane.The assignment of the C-20 configuration in the latter compound was supported by the analysis of Eu(fod)3-induced 1H NMR chemical shifts in the two C-20 epimers synthesized from lupeol. - Key Word Index: Lawsonia inermis; Lythraceae; henna; triterpenoids; 30-hydroxylupeol; 30-hydroxylupanol.

Side chain oxidation of lupeol: A reinvestigation

Oxidation of lupeol with m-chloroperbenzoic acid yields lup-20-norketone-3β-ol (6), lup-20(29)-ene-3β,30-diol (7) and lup-20-al-3β-ol (8).Formation of the compounds 7 and 8 from lupeol is being reported for the first time.

Lichens and Fungi. XVIII. Extractives from Pseudocyphellaria rubella

Twenty lupane triterpenoids including five (20RS)-epimeric pairs have been isolated from the chloroform extractives of the lichen Pseudocyphellaria rubella.The utility of g.c.-m.s. procedures in the structural elucidation of the extractives, some of which were complex mixtures is discussed.