20080-79-9Relevant academic research and scientific papers
Decarboxylative Fluorination of 2-Pyridylacetates
Kawanishi, Ryouta,Phongphane, Lacksany,Iwasa, Seiji,Shibatomi, Kazutaka
, p. 7453 - 7456 (2019)
Syntheses of substituted pyridines and fluorinated compounds, which are often pharmaceutical targets, are important objectives in organic chemistry. Herein, we found that decarboxylative fluorination of lithium 2-pyridylacetates occur under catalyst-free conditions. The phenomenon can be applied to one-pot transformation of substituted methyl 2-pyridylacetate to 2-(fluoroalkyl)pyridine by decarboxylative fluorination of the intermediate lithium 2-pyridylacetate. This method was also applied to the syntheses of 2-(difluoroalkyl)pyridines.
