200807-26-7Relevant academic research and scientific papers
Two Syntheses of Manoalide via Heteroatom-Assisted Alkyne Carbometallation
Bury, Paul,Hareau, Georges,Kocienski, Philip,Dhanak, Dashyant
, p. 8793 - 8808 (1994)
Two approaches to the sesterterpenoid phospholipase A2 inhibitors seco-manoalide (3) and manoalide (1) are described based on carbometallation of propargylic alcohols to generate the functionalised C6-C7 trisubstituted alkene.Both syntheses also deploy the photooxidation of a furan in order to generate a 4-substituted 5-hydroxy-2(5H)-furanone moiety.
