200862-25-5

Upstream product

• 98-86-2 acetophenone 
• 141-52-6 sodium ethanolate 
• 81376-51-4 (E)-3-(benzylamino)-3-(thiomethyl)-1-phenylprop-2-en-1-one 
• 100-46-9 benzylamine 
• 13636-88-9 3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 16516-19-1 O-ethyl 3-oxo-3-phenylpropanethioate 
• 110921-61-4 O-ethyl 3-hydroxy-3-phenyl-2-propenethioate 

Downstream Products

• 101476-69-1 Benzyl-(5-phenyl-2H-pyrazol-3-yl)-amine 

Relevant academic research and scientific papers

Copper-Catalyzed Formal Carbene Migratory Insertion into Internal Olefinic C=C Bonds with N-Tosylhydrazones to Access Iminofuran and 2(3H)-Furanone Derivatives

Efficient copper-catalyzed formal carbene migratory insertion into the olefinic C=C bonds of internal olefins, that is, α-oxo ketene N,S-acetals, has been achieved by means of N-tosylhydrazones of ketones as the carbene precursors. Iminofuran derivatives

Efficient regiocontrolled synthesis and antimicrobial activity of pyrazoles

A series of 1,5-diphenyl-1H-pyrazol-3-amines, 3-ethoxy-5-phenyl-1H- pyrazole, 5-ethoxy-1,3-diphenyl-1H-pyrazole and 3-ethoxy-1,5-diphenyl-1H- pyrazole were efficiently prepared from the regiocontrolled cyclization of α-oxoketene O,N-acetals and/or β-oxo thioxoesters with hydrazine derivatives using montmorillonite K-10 as solid support with ultrasound. The antimicrobial activity of the heterocyclic compounds was evaluated by direct bioautography test. Georg Thieme Verlag Stuttgart.

Synthesis of aminopyrazoles from α- oxoketene O,N-acetals using Montmorillonite K-10/Ultrasound

5(3)-Amino-3(5) phenylpyrazoles 3a-f have been conveniently prepared by condensation of α-oxoketene O,N-acetals 2a-g with hydrazine using montmorillonite K-10 as solid support under sonication.

Mild synthesis of α-oxoketene O,N-acetals from β-oxothioxo esters and amines

α-Oxoketene O,N-acetals were prepared from β-oxothiono esters and primary amines in the presence of Methylamine at room temperature within several hours in good yields.