200875-36-1

Basic information

• Product Name: Naphthalene, 2-bromo-7-methoxy- (9CI)
• Synonyms: Naphthalene, 2-bromo-7-methoxy- (9CI);2-Bromo-7-methoxynaphthalene
• CAS NO: 200875-36-1
• Molecular Formula: C11H9BrO
• Molecular Weight: 237.09256
• Product Categories: NAPHTALENE
• Mol File: 200875-36-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 97.5-98 °C(Solv: ethanol (64-17-5))
• Boiling Point: 324.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.447±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Naphthalene, 2-bromo-7-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene, 2-bromo-7-methoxy- (9CI)(200875-36-1)
• EPA Substance Registry System: Naphthalene, 2-bromo-7-methoxy- (9CI)(200875-36-1)

Safety Data

• Hazardous Substances Data: 200875-36-1(Hazardous Substances Data)

Usage

General Description

The chemical compound Naphthalene, 2-bromo-7-methoxy- (9CI) is a derivative of naphthalene, a polycyclic aromatic hydrocarbon commonly used in mothballs and as a precursor for the production of various dyes and other chemicals. The addition of a bromine atom and a methoxy group to the naphthalene structure imparts new chemical and physical properties to the compound, making it potentially useful in organic synthesis and as a research compound. However, it is important to note that naphthalene and its derivatives have been linked to negative health effects, including potential carcinogenicity and toxicity to the liver, kidneys, and central nervous system, so caution is advised when handling and using this chemical.

Upstream product

• 116230-30-9 7-bromonaphthalen-2-ol 
• 77-78-1 dimethyl sulfate 
• 582-17-2 2,7-Dihydroxynaphthalene 
• 74-88-4 methyl iodide 

Downstream Products

• 1608468-12-7 1-phenyl-3,3-dimethyl-9'-(9H-carbazol-9-yl)-spiroindolinenaphthoxadine 

Relevant articles and documents

Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and B–Z DNA Transition

The 2,13-dimethoxy[5]helicene–spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B-DNA by the accompanying induction of its (P)-chirality together with the B-to-Z helicity change of the duplex DNA, [(dC-dG)3]2/

PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS

In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating inflammatory disease, neurological disorders and cancer using the compounds of the invention.

Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is implicated in the regulation of inflammation, cell proliferation, and neurological disorders. MIF is also an enzyme that functions as a keto–enol tautomerase. Most potent MIF tautomerase inhibitors incorporate a phenol, which hydrogen bonds to Asn97 in the active site. Starting from a 113-μm docking hit, we report results of structure-based and computer-aided design that have provided substituted pyrazoles as phenol alternatives with potencies of 60–70 nm. Crystal structures of complexes of MIF with the pyrazoles highlight the contributions of hydrogen bonding with Lys32 and Asn97, and aryl–aryl interactions with Tyr36, Tyr95, and Phe113 to the binding.