200879-84-1Relevant academic research and scientific papers
A convenient one-pot synthesis of 6-trifluoromethyl-pyridines
Katsuyama, Isamu,Ogawa, Seiya,Nakamura, Hiroko,Yamaguchi, Yoshihiro,Funabiki, Kazumasa,Matsui, Masaki,Muramatsu, Hiroshige,Shibata, Katsuyoshi
, p. 779 - 785 (1998)
α,β-Unsaturated trifluoromethyl ketones (1) react with primary enamines (2) such as β-aminocrotononitrile and β-aminocrotonates in the presence of phosphorus oxychloride / pyridine adsorbed on silica gel and manganese dioxide, providing good to high yield
A convenient and regioselective synthesis of 4-trifluoromethylpyridines
Katsuyama,Ogawa,Yamaguchi,Funabiki,Matsui,Muramatsu,Shibata
, p. 1321 - 1324 (2007/10/03)
Trifluoromethyl-substituted β-diketones regioselectively react with primary enamines such as β-aminocrotononitrile and ethyl β-aminocrotonate, providing moderate to good yields of 4-trifluoromethylpyridines.
