A convenient one-pot synthesis of 6-trifluoromethyl-pyridines

DOI: 10.3987/com-98-8102

Source and publish data:

Heterocycles p. 779 - 785 (1998)

Update date:2022-08-03

Topics:

Authors:

Katsuyama, Isamu

Ogawa, Seiya

Nakamura, Hiroko

Yamaguchi, Yoshihiro

Funabiki, Kazumasa

Matsui, Masaki

Muramatsu, Hiroshige

Shibata, Katsuyoshi

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Article abstract of DOI:10.3987/com-98-8102

α,β-Unsaturated trifluoromethyl ketones (1) react with primary enamines (2) such as β-aminocrotononitrile and β-aminocrotonates in the presence of phosphorus oxychloride / pyridine adsorbed on silica gel and manganese dioxide, providing good to high yield

Full text of DOI:10.3987/com-98-8102

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Product name:3-cyano-1,4-dihydro-2-methyl-4-phenyl-6-trifluoromethylpyridine

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