20099-92-7Relevant academic research and scientific papers
Solvent-Free Synthesis of α-Amino Ketones from α-Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement
Li, Ling-Yu,Zeng, Qing-Le,Li, Guang-Xun,Tang, Zhuo
, p. 694 - 699 (2019)
Heyns rearrangement have been famous for carbohydrate chemists for several decades. However, this reaction was underrated as a useful method for synthetic chemists due to preparative shortcomings. Herein we developed an efficient method for the synthesis of pharmaceutically important α-amino ketones from readily available α-hydroxy ketones and secondary amines through a tandem reaction sequence based on Heyns rearrangement. The reaction smoothly proceeded by using catalytic PTSA as catalyst without solvent. Primary and secondary α-hydroxy ketones were readily used and regioselectively afforded the correspondingly α-amino ketones with moderate yield.
A New Thiazolium Salt-Catalyzed Synthesis of α-Aminoketones from Aldehydes and Iminium Salts
Castells, J.,Lopez-Calahorra, F.,Bassedas, M.,Urrios, P.
, p. 314 - 315 (2007/10/02)
A new reaction, closely related to both the classical Mannich reaction and the benzoin condensation, affords α-aminoketones from aldehydes and in situ prepared N-methylenemorpholinium or N-methylenepiperidinium salts.
