20099-96-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Bromophenyl)-2-morpholinoethanone is used as a reagent for the preparation of various pharmaceutical compounds. Its unique structure with a bromine atom and morpholino group allows it to be a key component in the synthesis of complex organic molecules, contributing to the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(4-Bromophenyl)-2-morpholinoethanone serves as a valuable intermediate for the preparation of a wide range of organic molecules. Its versatility in reacting with other compounds makes it an essential building block for creating new chemical entities with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 110-91-8 morpholine 
• 99-90-1 para-bromoacetophenone 
• 3343-45-1 4-bromo-2-hydroxyacetophenone 

Downstream Products

• 1127405-08-6 1-(4-bromophenyl)-2-(morpholin-4-yl)ethane-1,2-dione 

Relevant academic research and scientific papers

Solvent-Free Synthesis of α-Amino Ketones from α-Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement

Heyns rearrangement have been famous for carbohydrate chemists for several decades. However, this reaction was underrated as a useful method for synthetic chemists due to preparative shortcomings. Herein we developed an efficient method for the synthesis of pharmaceutically important α-amino ketones from readily available α-hydroxy ketones and secondary amines through a tandem reaction sequence based on Heyns rearrangement. The reaction smoothly proceeded by using catalytic PTSA as catalyst without solvent. Primary and secondary α-hydroxy ketones were readily used and regioselectively afforded the correspondingly α-amino ketones with moderate yield.

Coupling of methyl ketones and primary or secondary amines leading to α-ketoamides

A metal-free oxidative coupling of methyl ketones and primary or secondary amines to α-ketoamides has been developed. Four intermediates, α-iodoketone, α-aminoketone, iminium intermediate, and α-hydroxy amine have been identified through a series of control experiments. The atom-economic methodology can be scaled-up, tolerates a variety of functional groups, and is operationally simple.

MORPHOLINYL AND PYRROLIDINYL ANALOGS

The present invention relates to morpholinyl, and pyrrolidinyl analogs, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.