2010-16-4Relevant academic research and scientific papers
Cu(I) arylsulfonate π-complexes with 3-allyl-2-thiohydantoin: The role of the weak interactions in structural organization
Fedorchuk, Andrii,Goreshnik, Evgeny,Slyvka, Yurii,Mys'kiv, Marian
, p. 1148 - 1154 (2021/05/14)
The present work is directed toward preparation and structural characterization of two novel Cu(I) arylsulfonate π-complexes with 3-allyl-2-thiohydantoin, namely [Cu2(Hath)4](C6H5SO3)2(1) a
An unusual diverse coordination of silver(I) with N-allylthiohydantoin ligand in the presence of benzene- and p-toluenesulfonate anions
Fedorchuk,Slyvka, Yu.I.,Kinzhybalo,Lis,Mys'kiv
, p. 79 - 86 (2018/09/22)
Crystalline silver(I) coordination compounds [Ag2(HL)4(C6H5SO3)2]·0.5C3H7OH (1) and [Ag2(HL)(L)(CH3C6H4SO3)] (2) (HL = 3-(prop-2-en-1-yl)-2-thioxoimidazolidin-4-one) have been obtained using silver(I) salts and the organic ligand HL. Three independent Ag(I) atoms in crystal 1 adopt exclusively different coordination environment: tetragonal pyramidal, seesaw and distorted tetrahedral. In crystal 2 metal ions coordination polyhedra are characterized by seesaw and distorted tetrahedral arrangements. Thiohydantoin molecules in both structures are attached to Ag(I) only through thiohydantoin S-atom, while its anionic form in 2 plays a role of N,S-linker. C6H5SO3? anions in 1 are bound to the Ag(I) ions in a bridging mode, connecting silver ions into serpentine-like {Ag4(C6H5SO3)4}n chains, within which silver ions are additionally bind with μ2-S atoms of HL. Simultaneous coordination of HL and L? moieties in polymeric chains of 2 allow the formation of Ag….Ag metallophilic interactions with the distance range of 2.99–3.13 ?.
Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin- 4-one (thiohydantoin) drug derivatives
Jha, Sushil,Silversides, Jon D.,Boyle, Ross W.,Archibald, Stephen J.
experimental part, p. 1730 - 1739 (2011/12/02)
Hydantoins have been known as medicinally active compounds since the 1940s and thiohydantoin derivatives are currently undergoing clinical trials as potent androgen receptor antagonist drugs. Control of solid state properties including the formation of drug polymorphs is important to the pharmaceutical industry, and frequently results from different H-bonded motifs. N-H thiohydantoins show formation of H-bonded arrays in the solid state. Two novel and five known thiohydantoin derivatives were synthesised via reaction of alkyl isothiocyanates with amino acid methyl esters. X-Ray crystallographic data were obtained for all seven compounds showing that four of the structures contain hydrogen bonded dimeric units linked via N-H...S interactions and three of the structures have N-H...O linked H-bonded chains. The Royal Society of Chemistry 2010.
SYNTHESIS OF IMIDAZOLE-2-THIONES VIA THIOHYDANTOINS
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Page/Page column 27-28, (2010/11/26)
The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole- 2-thione.
Sulfur glycosylation reactions involving 3-allyl-2-thiohydantoin nucleoside bases as potential antiviral and antitumor agents
Khodair, Ahmed I.,Gesson, Jean-Pierre
, p. 167 - 190 (2007/10/03)
3-Allyl-5-(Z)-arylidene-2-thiohydantoins 8a-f were synthesized from the direct condensation of the aromatic aldehydes 7a-f with 3-allyl-2-thiohydantoin (6), which in turn was prepared from the reaction of glycine and allyl isothiocyanate. The alkylation o
