20101-88-6Relevant articles and documents
Pd(quinoline-8-carboxylate)2 as a low-priced, phosphine-free catalyst for heck and suzuki reactions
Cui, Xin,Li, Juan,Zhang, Zhi-Ping,Fu, Yao,Liu, Lei,Guo, Qing-Xiang
, p. 9342 - 9345 (2008/03/13)
(Chemical Equation Presented) N,O-Bidentate compounds were systematically evaluated as phosphine-free ligands for Pd-catalyzed C-C bond-formation reactions through kinetic measurements. Pd(quinoline-8-carboxylate)2 was identified as one of the most efficient, yet still low-priced, phosphine-free catalysts for Heck as well as Suzuki reactions of unactivated aryl bromides with high turnover numbers up to ca. 10,000.
Amides of amphoteric polyene macrolide antibiotics
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, (2008/06/13)
The invention relates to amides of polyene macrolide antibiotics and their derivatives characterized by the general formula I, STR1 where R is the polyene macrolide, R1 is an alkyl or isoalkyl chain of from one to eighteen carbons, unsubstituted or substituted with a primary or secondary amine; where R2 is an hydrogen or R1 or R1 and R2 are joined through the nitrogen to form a heterocyclic ring. The method of preparation of these substances according to our invention depends upon the reaction of the polyene macrolide or its derivative in which the carboxylic group is activated; in the environment of an organic solvent or mixture of solvents and in the presence of a substance neutralizing the acid; with a compound containing an amino group; leaving upon completion of the reaction; and precipitation of the product from the reaction mixture, by addition of ethyl ether or a mixture of ethyl ether with hydrocarbons; isolation and purification of the product by means of known methods.