201034-31-3

Upstream product

• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 108-24-7 acetic anhydride 
• 201034-30-2 2',4'-difluoro-2-[(2-hydroxyethyl)thio]acetophenone 

Downstream Products

• 201034-35-7 2-(2-acetoxyethylthio)-2,2,2',4'-tetrafluoroacetophenone 
• 201034-46-0 2-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propylthio]ethyl acetate 
• 201034-54-0 2-(2,4-difluorophenyl)-1,1-difluoro-1-[(2-hydroxyethyl)thio]-3-(1H-1,2,4-triazol-1-yl)-2-propanol 
• 201034-39-1 2-[[[2-(2,4-difluorophenyl)-2-oxiranyl]difluoromethyl]thio]ethyl acetate 

Relevant academic research and scientific papers

New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety

New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via α,α-difluoro-α-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus

α, α-gem-difluorination of α-(alkylthio)acetophenone derivatives with N-Fluoropyridinium salts

The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).