201036-12-6Relevant academic research and scientific papers
Substance, with protein tyrosine kinase inhibitory activity, and preparation method and application thereof
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Paragraph 0173-0175, (2020/04/08)
The invention discloses substances having a protein tyrosine kinase inhibitory activity, and a preparation method and a use thereof; the substances are compounds having the structure represented by the general formula V, wherein in the formula V, X is sul
Metal-free oxidative coupling of alkyl chlorides with thiols: An efficient access to sulfoxides
Liu, Qian,Zhao, Xiaoqian,Xu, Feng,Li, Gaoqiang
supporting information, (2019/12/27)
An efficient and step-economical access to sulfoxides from thiols and alkyl halides in the presence of I2O5 and DBU via direct oxidative couplings is described here. It is the first case that combined Williamson sulfide synthesis and subsequent sulfide oxidation into one step manipulation for sulfoxides preparation. This protocol features wide substrate scope, mild and metal-free conditons, the use of naturally abundant starting materials and avoidance of over-oxidation.
Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD
Tang, Lin,Peng, Tao,Wang, Gang,Wen, Xiaoxue,Sun, Yunbo,Zhang, Shouguo,Liu, Shuchen,Wang, Lin
, p. 625 - 631 (2018/05/03)
In this work, a series of novel benzyl naphthyl sulfoxides (sulfones) derived from Ex-RAD were designed and synthesized as potential radioprotective agents. Some of the compounds considerably protected HUVECs against 60Co γ-irradiation, accompanied by the absence of cytotoxicity. Compared to Ex-RAD, compound 8n not only exhibited a significant protective effect on cell survival and radiation-induced DNA damage, but also remarkably enhanced the survival (100%) of mice in 30 days after being exposed to irradiation. The results suggested that some target compounds are valuable for further research as promising radioprotectors.
Palladium/PC-Phos-Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications
Wang, Lei,Chen, Mingjie,Zhang, Peichao,Li, Wenbo,Zhang, Junliang
, p. 3467 - 3473 (2018/03/13)
Herein we reported an efficient palladium-catalyzed enantioselective arylation of both alkyl and aryl sulfenate anions to deliver various chiral sulfoxides in good yields (up to 98%) with excellent enantioselectivities (up to 99% ee) by the use of our developed chiral O,P-ligands (PC-Phos). PC-Phos are easily prepared in short steps from inexpensive commercially available starting materials. The single-crystal structure of the PC4/PdCl2 showed that a rarely observed 11-membered ring was formed via the O,P-coordination with the palladium(II) center. The salient features of this method include general substrate scope, ease of scale-up, applicable to the late-stage modification of bioactive compounds, and the synthesis of a marketed medicine Sulindac.
Chiral microporous Ti(salan)-based metal-organic frameworks for asymmetric sulfoxidation
Zhu, Chengfeng,Chen, Xu,Yang, Zhiwei,Du, Xia,Liu, Yan,Cui, Yong
, p. 7120 - 7122 (2013/08/23)
Chiral porous metal-metallosalan frameworks are constructed from an unsymmetrical chiral pyridinecarboxylate ligand derived from Ti(salan) and are shown to be heterogeneous catalysts for asymmetric oxidation of thioethers to sulfoxides.
2-(trimethylsilyl)ethyl sulfoxides as a convenient source of sulfenate anions
Foucoin, Florian,Caupene, Caroline,Lohier, Jean-Francois,Santos, Jana Sopkova De Oliveira,Perrio, Stephane,Metzner, Patrick
, p. 1315 - 1324 (2008/02/13)
The present report describes the novel and smooth generation of sulfenate salts by fluoride-mediated cleavage of 2-(trimethylsilyl)ethyl sulfoxides. Efficiency of the process was elucidated through further reaction with alkyl halides to give stable sulfox
Photochemistry of benzyl β-naphthyl sulfoxide and characterization of the β-naphthylsulfinyl radical
Guo, Yushen,Darmanyan, Alexandre P.,Jenks, William S.
, p. 8619 - 8622 (2007/10/03)
Photolysis of benzyl β-naphthyl sulfoxide results mainly in α-cleavage. The isomeric sulfenic ester is the major product. Because the triplet energies of both the sulfoxide and sulfenic ester are below that of acetone, in contrast to the previously studied phenyl and tolyl cases, interpretation of sensitization experiments is straightforward. The sulfinyl radical is characterized by transient absorption and a model is proposed to account for its reactivity with nitroxide radicals.
