201054-30-0

Upstream product

• 201054-34-4 [(4R,5S,6S)-6-(2-Benzyloxy-ethyl)-5-methyl-2-phenyl-[1,3]dioxan-4-yl]-acetic acid ethyl ester 
• 149916-84-7 (E)-(4R,5S)-7-Benzyloxy-5-hydroxy-4-methyl-hept-2-enoic acid ethyl ester 
• 959125-19-0 (E)-ethyl 3-((2R,3S)-3-(2-(benzyloxy)ethyl)oxiran-2-yl)acrylate 

Downstream Products

• 201054-38-8 (3R,4S,5S,6S)-6-(2-Benzyloxy-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-tetrahydro-pyran-2-one 
• 201054-36-6 (3R,4S,5R,6S)-6-(2-Benzyloxy-ethyl)-4-hydroxy-3,5-dimethyl-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

Expeditious and stereoselective synthesis of chiral trans -β-hydroxy-δ-lactone systems

Expeditious and stereoselective synthesis of chiral trans-β-hydroxy-δ-lactone systems starting from γ,δ-epoxy acrylates is described which involves the regioselective ring opening of an epoxide and the intramolecular conjugate addition of a hemiacetal alkoxide anion of δ-hydroxy-α,β-unsaturated esters as key steps.

Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide

A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylat