201054-34-4

Upstream product

• 100-52-7 benzaldehyde 
• 149916-84-7 (E)-(4R,5S)-7-Benzyloxy-5-hydroxy-4-methyl-hept-2-enoic acid ethyl ester 
• 70542-83-5 ethyl (2E)-5-(benzyloxy)pent-2-enoate 
• 89923-31-9 (E)-5-(benzyloxy)pent-2-en-1-ol 
• 126107-76-4 (2R,3S)-3-[2-(benzyloxy)ethyl]oxiran-2-methanol 
• 959125-19-0 (E)-ethyl 3-((2R,3S)-3-(2-(benzyloxy)ethyl)oxiran-2-yl)acrylate 

Downstream Products

• 201054-38-8 (3R,4S,5S,6S)-6-(2-Benzyloxy-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-tetrahydro-pyran-2-one 
• 201054-36-6 (3R,4S,5R,6S)-6-(2-Benzyloxy-ethyl)-4-hydroxy-3,5-dimethyl-tetrahydro-pyran-2-one 
• 201054-30-0 (4R,5R,6S)-6-(2-Benzyloxy-ethyl)-4-hydroxy-5-methyl-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

Expeditious and stereoselective synthesis of chiral trans -β-hydroxy-δ-lactone systems

Expeditious and stereoselective synthesis of chiral trans-β-hydroxy-δ-lactone systems starting from γ,δ-epoxy acrylates is described which involves the regioselective ring opening of an epoxide and the intramolecular conjugate addition of a hemiacetal alkoxide anion of δ-hydroxy-α,β-unsaturated esters as key steps.

Stereoselective synthesis of the C1-C7 segment of (+)-discodermolide

A new and highly stereoselective synthesis of the C1-C7 segment of (+)-discodermolide, the marine natural product having the potent immunosuppressive activity, is described in which the stereospecific methylation of γ,δ-epoxy acrylat