20107-08-8Relevant academic research and scientific papers
Metal-free and highly regioselective synthesis of N-heteroaryl substituted pyrazoles from α,β-unsaturated N-tosylhydrazones and heteroaryl chlorides
Zeng, Lin,Guo, Xiao-Qiang,Yang, Zai-Jun,Gan, Ya,Chen, Lian-Mei,Kang, Tai-Ran
, (2019)
A cascade cyclization/nucleophilic aromatic substitution (SNAr) reaction of α,β-unsaturated N-tosylhydrazones with N-heteroaryl chlorides was developed for the synthesis of N-heteroaryl pyrazole derivatives. This one-pot reaction provided bi(he
Metal-Free Synthesis of Pyrazoles from 1,3-Diarylpropenes and Hydrazines via Multiple Inter-/Intramolecular C–H Aminations
Tang, Li,Ma, Minyan,Zhang, Qi,Luo, Huan,Wang, Tao,Chai, Yonghai
, p. 2610 - 2620 (2017/08/16)
A facile and metal-free access to pyrazoles from 1,3-diarylpropenes and hydrazines via multiple inter-/intramolecular C-H aminations was described. Under the neutral and mild 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) oxidative conditions, various disubstituted pyrazoles were synthesized in moderate to excellent yields. This method provides a pot- and step-economic strategy for the construction of pyrazoles, especially those for drug discovery. (Figure presented.).
