20108-91-2

Upstream product

• 16934-77-3 Neoisomenthylamine 
• 79-04-9 chloroacetyl chloride 
• 160399-90-6 isomenthylamine 
• 2216-54-8 L-menthylamine 
• 2216-51-5 (-)-menthol 
• 107-14-2 chloroacetonitrile 
• 7231-40-5 (+)-(1R,3S,4S)-neomenthylamine 

Downstream Products

• 866422-91-5 2-(Benzyl-methyl-amino)-N-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-acetamide 
• 866422-93-7 N-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-2-{[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexylcarbamoyl)-methyl]-methyl-amino}-acetamide 

Relevant academic research and scientific papers

Indium-Triflate-Catalyzed Ritter Reaction in Liquid Sulfur Dioxide

The use of liquid sulfur dioxide as a reaction solvent facilitates the Ritter reaction between alcohols and nitriles. In(OTf)3 was found to be a viable catalyst for this transformation. The newly developed catalytic conditions for the Ritter reaction were successfully applied to the synthesis of various amides, which were formed in good to excellent yields. The catalytic activation of secondary alcohols for Ritter reactions in liquid sulfur dioxide was also found to be effective.

L-Menthol as new scaffold for designing chiral phase-transfer catalysts

We herein report, a new class of chiral phase-transfer catalysts derived from l-menthol. The moderately good enantioselectivity exhibited by these catalysts have been explained based on single crystal X-ray data and molecular modelling studies.