201135-17-3Relevant academic research and scientific papers
A General Strategy to Synthesize ADP-7-Azido-heptose and ADP-Azido-mannoses and Their Heptosyltransferase Binding Properties
Li, Tianlei,Tikad, Abdellatif,Fu, Huixiao,Milicaj, Jozafina,Castro, Colleen D.,Lacritick, Marine,Pan, Weidong,Taylor, Erika A.,Vincent, Stphan P.
supporting information, p. 1638 - 1642 (2021/03/08)
The multistep synthesis of a novel ADP-7-azido-7-deoxy-l-glycero-β-d-manno-heptopyranoside 2a and several analogues as heptosyltransferase ligands is described. The synthesis of the key intermediate heptoside-1-β-phosphate 3a involved a β-stereoselective
Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V
Kaneko, Mitsuaki,Kanie, Osamu,Kajimoto, Tetsuya,Wong, Chi-Huey
, p. 2809 - 2812 (2007/10/03)
The tumor related enzyme N-acetylglucosaminyltransferase V catalyzes the transfer of GlcNAc to OH-6 of branching Man to give complex oligosaccharide structures. A transition state analog inhibitor of this enzyme was designed and a model compound was synthesized to illustrate the feasibility of the synthetic strategy.
