201157-01-9Relevant academic research and scientific papers
Nucleophilic aromatic substitution with dialkoxycarbenes
Ross, Joseph P.,Couture, Philippe,Warkentin, John
, p. 1331 - 1335 (2007/10/03)
Dimethoxycarbene, generated at 110°C by thermolysis of 2,2-dimethoxy-5,5-dimethyl-Δ3-1,3,4-oxadiazoline, displaces fluoride from aromatic rings that are activated with electron-withdrawing groups. Intermolecular substitution on Sanger's reagent and on hexafluorobenzene are reported, together with intramolecular substitution by a dioxycarbene with a tethered aryl group.
