201231-65-4

Basic information

• Product Name: (R)-4-Benzyl-3-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-oxazolidin-2-one
• Synonyms: (R)-4-Benzyl-3-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-oxazolidin-2-one
• CAS NO: 201231-65-4
• Molecular Weight: 479.515
• Mol File: 201231-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-Benzyl-3-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Benzyl-3-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-oxazolidin-2-one(201231-65-4)
• EPA Substance Registry System: (R)-4-Benzyl-3-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-oxazolidin-2-one(201231-65-4)

Safety Data

• Hazardous Substances Data: 201231-65-4(Hazardous Substances Data)

Upstream product

• 110905-24-3 (4R)-3-(bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone 
• 603-35-0 triphenylphosphine 
• 275378-96-6 (R)-N-Carbamyl-phenylalanine methyl ester 
• 275378-91-1 ((R)-1-Hydroxymethyl-2-phenyl-ethyl)-urea 
• 3530-82-3 5-benzyl-hydantoin 
• 184714-56-5 (R)-4-benzyl-3-(2-chloroacetyl)oxazolidin-2-one 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 54896-72-9 (R)-3-phenyl-2-ureido-propionic acid 

Downstream Products

• 550334-60-6 (R)-4-benzyl-3-((2E,8E,10E)-dodeca-2,8,10-trienoyl)-oxazolidin-2-one 
• 922174-52-5 (4R,2'R,6'S)-3-(2',6'-dimethyl-7'-carboxyheptanoyl)-4-phenylmethyl-1,3-oxazolidin-2-one 
• 922174-50-3 (4R,2'R,6'R)-3-(2',6'-dimethyl-7'-carboxyheptanoyl)-4-phenylmethyl-1,3-oxazolidin-2-one 
• 922174-47-8 (4R,2'R,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one 
• 922174-46-7 (4R,2'R,6'R)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one 
• 922174-43-4 (4R,6'R)-3-[6'-methyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one 
• 922174-41-2 (4R,6'S)-3-[6'-methyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one 

Relevant articles and documents

N-carbamylamino alcohols as the precursors of oxazolidinones via nitrosation-deamination reaction

Oxazolidinones were effectively prepared from N-carbamylamino alcohols by treatment with nitrous acid, via N-nitroso compound as the intermediate. A new route to (R)-4-benzyloxazolidinone was developed starting from DL- phenylalanine, utilizing D-hydantoinase-catalyzed enantioselective hydrolysis of 5-benzylhydantoin under the dynamic kinetic resolution conditions, and the subsequent reduction to the precursor for the above-mentioned cyclization reaction, by taking advantage of the intermediates bearing an N-carbamylamino functionality.