275378-96-6

Basic information

• Product Name: (R)-N-Carbamyl-phenylalanine methyl ester
• Synonyms: (R)-N-Carbamyl-phenylalanine methyl ester
• CAS NO: 275378-96-6
• Molecular Weight: 222.244
• Mol File: 275378-96-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-Carbamyl-phenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-Carbamyl-phenylalanine methyl ester(275378-96-6)
• EPA Substance Registry System: (R)-N-Carbamyl-phenylalanine methyl ester(275378-96-6)

Safety Data

• Hazardous Substances Data: 275378-96-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 54896-72-9 (R)-3-phenyl-2-ureido-propionic acid 
• 3530-82-3 5-benzyl-hydantoin 

Downstream Products

• 201231-65-4 (R)-4-Benzyl-3-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-oxazolidin-2-one 
• 184714-56-5 (R)-4-benzyl-3-(2-chloroacetyl)oxazolidin-2-one 
• 110905-24-3 (4R)-3-(bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 275378-91-1 ((R)-1-Hydroxymethyl-2-phenyl-ethyl)-urea 

Relevant articles and documents

N-carbamylamino alcohols as the precursors of oxazolidinones via nitrosation-deamination reaction

Oxazolidinones were effectively prepared from N-carbamylamino alcohols by treatment with nitrous acid, via N-nitroso compound as the intermediate. A new route to (R)-4-benzyloxazolidinone was developed starting from DL- phenylalanine, utilizing D-hydantoinase-catalyzed enantioselective hydrolysis of 5-benzylhydantoin under the dynamic kinetic resolution conditions, and the subsequent reduction to the precursor for the above-mentioned cyclization reaction, by taking advantage of the intermediates bearing an N-carbamylamino functionality.