201338-71-8Relevant academic research and scientific papers
Synthesis of a trimeric gp120 epitope mimic conjugated to a T-helper peptide to improve antigenicity
Schellinger, Joan G.,Danan-Leon, Lieza M.,Hoch, Jessica A.,Kassa, Aemro,Srivastava, Indresh,Davis, David,Gervay-Hague, Jacquelyn
supporting information; experimental part, p. 3230 - 3233 (2011/05/04)
A fully synthetic trivalent mimotope of gp120 conjugated to pan allelic HLA DR binding epitope was prepared using solid-phase peptide synthesis and optimized copper-catalyzed azide-alkyne cycloaddition. The methodology efficiently provides chemically uniform heteromultimeric peptide constructs with enhanced binding, avidity, and specificity toward an established HIV-neutralizing human antibody, MAb b12. The versatile synthetic strategy serves as a powerful platform for the development of synthetic peptides as potential HIV-1 vaccine candidates.
