201349-60-2

Usage

Structure

Consists of a furan ring attached to a carboxylic acid group and a 4-aminonaphthalen-1-yl group

Use

Building block in the synthesis of various pharmaceuticals and other organic compounds

Potential applications

Medicinal chemistry and drug discovery

Potential biological activities

Area of interest for further research in the pharmaceutical industry

Upstream product

• 611-13-2 2-furoic acid methyl ester 
• 90-11-9 1-Bromonaphthalene 
• 854401-91-5 methyl 5-(naphthalen-1-yl)furan-2-carboxylate 
• 51792-36-0 5-(naphthalen-1-yl)furan-2-carbaldehyde 
• 13922-41-3 1-Naphthylboronic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 

Relevant academic research and scientific papers

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Methyl 2-furoate: An alternative reagent to furan for palladium-catalysed direct arylation

The palladium-catalysed direct arylation of methyl 2-furoate with aryl bromides was studied. The use of KOAc as the base, dimethylacetamide (DMAc) as the solvent and Pd(OAc)2 as the catalyst was found to give 5-arylfurans regioselectively and without decarboxylation. These methyl 5-aryl-2-furoates gave 2,5-diarylfurans by decarboxylative coupling by using Pd(OAc)2 as the catalyst. Methyl 2-furoate thus represents a convenient alternative substrate to furan for the synthesis of mono- or poly-arylated furans.