201414-05-3Relevant academic research and scientific papers
N-linked glycoside/glucuronide conjugates of retinoids: Acitretin
Balakrishnan,Gilbert,Brueggemeier,Curley Jr.
, p. 3033 - 3038 (1997)
Glucuronide conjugates of retinoids have been found to be active metabolites of the parent molecules. However, O-acylglucuronide retinoids are liable to hydrolysis and retinoid ring oxidation. We have prepared stable N-linked glycosides of acitretin in efforts to overcome these problems. The synthesis and preliminary biological studies of the analogs are reported.
