N-linked glycoside/glucuronide conjugates of retinoids: Acitretin

Article abstract of DOI:10.1016/S0960-894X(97)10140-8

Glucuronide conjugates of retinoids have been found to be active metabolites of the parent molecules. However, O-acylglucuronide retinoids are liable to hydrolysis and retinoid ring oxidation. We have prepared stable N-linked glycosides of acitretin in efforts to overcome these problems. The synthesis and preliminary biological studies of the analogs are reported.