201419-22-9

Upstream product

• 100-52-7 benzaldehyde 
• 201419-21-8 Methyl (2E,5S,7R)-7-benzyloxy-5-hydroxy-2,9-decanedienoate 
• 201419-20-7 Methyl (2E,5S,7R)-7-benzyloxy-5-dimethylphenylsilyl-2,9-decanedienoate 
• 251908-42-6 (2'E,4S,5'S)-4-tert-Butyl-3-[5'-dimethylphenylsilyl-7'-oxo-2'-heptenoyl]-oxazolidin-2-one 
• 251908-43-7 (2'E,4S,5'S,7'R)-4-tert-Butyl-3-[5'-dimethylphenylsilyl-7'-hydroxy-2',9'-decanedienoyl]-oxazolidin-2-one 
• 251908-45-9 (2'E,4S,5'S,7'R)-4-tert-Butyl-3-[7'-benzyloxy-5'-dimethylphenylsilyl-2',9'-decanedienoyl]-oxazolidin-2-one 
• 201419-19-4 (E)-(S)-5-(Dimethyl-phenyl-silanyl)-7-oxo-hept-2-enoic acid methyl ester 
• 201419-18-3 (E)-(S)-7-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(dimethyl-phenyl-silanyl)-7-oxo-hept-5-enal 

Downstream Products

• 201419-23-0 [(2R,4R,6R)-6-((R)-5-Acetoxy-2-benzyloxy-pentyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

General and asymmetric synthesis of protected 1,3,5-triols with pendant functional groups

A stereoselective synthesis of enantiomerically pure 1,3,5-triols of any configuration has been developed. These triols carry suitable functional groups at the termini of the chain which should allow for easy and efficient coupling of two building blocks.

Enantioselective polyol synthesis via the cope rearrangement of chiral aldol products. A synthesis of the C1-C10-fragment of nystatin A1

A stereoselective synthesis of a fully protected C1-C10-polyol- fragment of nystatin A1 is described. The oxy-Cope rearrangement of the chiral aldol product 1 affords the aldehyde 3 as the key intermediate which is converted into the natural product fragment by enantioselective allylboration and intramolecular conjugate addition of a hemiacetal-alkoxide.