201419-23-0Relevant academic research and scientific papers
Enantioselective polyol synthesis via the cope rearrangement of chiral aldol products. A synthesis of the C1-C10-fragment of nystatin A1
Schneider, Christoph,Rehfeuter, Markus
, p. 9 - 12 (2007/10/03)
A stereoselective synthesis of a fully protected C1-C10-polyol- fragment of nystatin A1 is described. The oxy-Cope rearrangement of the chiral aldol product 1 affords the aldehyde 3 as the key intermediate which is converted into the natural product fragment by enantioselective allylboration and intramolecular conjugate addition of a hemiacetal-alkoxide.
