20143-46-8

Upstream product

• 575-90-6 2,6-dichlorophenoxyacetic acid 
• 87-65-0 2,6-Dichlorophenol 

Downstream Products

• 900502-10-5 C₁₆H₁₆Cl₂NO₅P 
• 904702-60-9 O,O-dimethyl α-(2,6-dichlorophenoxyacetoxy)-3-nitrobenzylphosphonate 
• 110984-68-4 2-(2,6-Dichloro-phenoxy)-N-(5-methylsulfanyl-2H-[1,2,4]triazol-3-yl)-acetamide 
• 110984-35-5 1-(5-Amino-3-methylsulfanyl-[1,2,4]triazol-1-yl)-2-(2,6-dichloro-phenoxy)-ethanone 

Relevant academic research and scientific papers

Synthesis and Biological Activity of O-Methyl Methyl 1-(Substituted Phenoxyacetoxy)-1-(thien-2-yl)methylphosphinates

A series of novel O-methyl methyl 1-(substituted phenoxyacetoxy)-1-(thien-2-yl)methylphosphinates 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h were synthesized. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 5c, 5d, and 5g possess 90-100% inhibition against the tested plants at the concentration of 10 mg/L and 100 mg/L, whereas the title compounds 5a, 5b, 5c, and 5h possess 70-94% inhibition against Phyricularia grisea and Sclerotinia sclerotiorum at the concentration of 50 mg/L.

Synthesis and biological activity of 1-(Substituted phenoxyacetoxy)- 1-(pyridin-2-yl or thien-2-yl)methylphosphonates

A series of novel O,O-dimethyl 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates 6a-n and 7a-d were synthesized. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a, 6c, 6l, 6m, and 7d possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b, 6g-h and 6n possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50mg/L.

Synthesis and Herbicidal Activities of Sodium Methyl(α-(Substituted Phenoxyacetoxy)Alkyl)Phosphinates

A series of sodium methyl(α-(substituted phenoxyacetoxy)alkyl)phosphinates was designed and synthesized. Their structures were confirmed by IR, 1H NMR and elemental analysis, and some of them were further confirmed by MS. The results of bioassay showed that most of title compounds exhibited moderate to good herbicidal activities against the root of barnyard grass and rape at 10～100 mg/L.

Studies of O,O-Dimethyl α-(2,4-Dichlorophenoxyacetoxy) ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex

On the basis of the previous work for optimization of O,O-diethyl α-(substituted phenoxyacetoxy)alkylphosphonates, further extensive syntheticmodifications were made to the substituents in alkylphosphonate and phenoxymoieties of the title compounds. New O,O-dimethyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized as potential inhibitors of pyruvate dehydorogenase complex (PDHc). Their herbicidal activity and efficacy in vitro against PDHc were examined. Some of these compounds exhibited significant herbicidal activity and were demonstrated to be effective inhibitors of PDHc from three different plants. The structure-activity relationships of these compounds including previously reported analogous compoundswere studied by examining their herbicidal activities. Both inhibitory potency against PDHc and herbicidal activity of title compounds could be increased greatly by optimizing substituent groups of the title compounds. O,O-Dimethyl α-(2,4- dichlorophenoxyacetoxy)ethylphosphonate (I-5), which acted as a competitive inhibitor of PDHc with much higher inhibitory potency against PDHc from Pisum sativum and Phaseolus radiatus than from Oryza sativa, was found to be themost effective compound against broadleaf weeds and showed potential utility as herbicide.

Synthesis and biological activity of α-oxo-2-pyridyl methyl phosphinates

In an attempt to discover novel compounds with high activity and low toxicity, a series of new O,O-dimethyl-α-(substituted phenoxyacetoxy)-2- pyridyl methyl phosphinates, 5a-5h, have been designed and synthesized by the reaction of substituted phenoxyacetic chloride with 1-hydroxy-2-pyridyl methyl phosphinate, The structures of all new compounds were characterized by elementary analysis, IR, 1H NMR, and MS spectroscopies. The results of preliminary bioassay indicate that most of the target compounds have excellent inhibitory activities on barnyard grass and rape. Copyright Taylor & Francis Group, LLC.

Synthesis and screening of certain aryloxyacetylaminoguanidines as potential antihypertensive agents

Ethyl aryloxyacetates (2a-k) have been synthesized either by the esterification of aryloxyacetic acids (1a-j) with ethanol in the presence of concentrated sulphuric acid or by reacting potassium naphthoxides with ethyl chloroacetate in dimethylformamide. Hydrazinolysis of either 1a, b, d, f, j or 2a-k furnishes the corresponding hydrazides (3). On the other hand, the acid chlorides (4f-h) have been prepared via the reaction of 1a-f with thionyl chloride in dry benzene, which on refluxing with aminoguanidine bicarbonate in dry benzene give the target aminoguanidine hydrochlorides (5a-h). Meanwhile, the desired aminoguanidine sulphates (5a-e) have been obtained by condensing 2a-e with S-methylisothiourea sulphate in aqueous ethanol. Additionally, the new aminotriazole sulphates (6a-h) are obtained either by refluxing 2a-h with S-methylisothiourea sulphate or by fusion of 1a,b, h, j with aminoguanidine sulphate. Structures of the new compounds are based on elemental analyses and IR, 1 HNMR and mass spectral data. Pharmacological screening, indicates that some of the newly synthesized compounds exhibit significant antihypertensive activity in both normal and renal hypertensive rats. Compound 5b produces significant decrease in the heart rate of normal rats. Compounds 5f and 5g have no significant effect. Compounds 5f, g, h have inhibition effect on the isolated rabbit intestine.