201530-79-2

Usage

Uses

Used in Pharmaceutical Industry:
Deferasirox Ethyl Ester is used as an iron chelator for the treatment of iron overload disorders. It helps in reducing the excess iron levels in the body, which can be caused by frequent blood transfusions or other conditions that lead to an accumulation of iron. By chelating iron, it prevents the harmful effects of iron overload on vital organs such as the liver, heart, and endocrine glands.
Used in Research Applications:
In the field of research, Deferasirox Ethyl Ester is used as a chemical probe to study the role of iron in various biological processes and diseases. It can be employed to investigate the effects of iron chelation on cellular functions, iron metabolism, and the development of iron-related disorders.
Used in Drug Development:
Deferasirox Ethyl Ester can be utilized in the development of new drugs targeting iron-related disorders or conditions where iron plays a crucial role. Its unique properties as an iron chelator make it a valuable compound for designing and synthesizing novel therapeutic agents.

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Relevant academic research and scientific papers

1,2,4-triazole compound, salt thereof and applications of compound and salt

The invention discloses a 1,2,4-triazole compound, salt thereof and applications of the compound and salt. The compound has a structural formula shown in the description, wherein R represents hydrogen, phenyl or substituted phenyl, and a substituted group of substituted phenyl is selected from carboxyl, an ester group, C1-4 alkyl, C1-4 alkoxy groups, C1-4 halogenated alkyl, C1-4 halogenated alkoxygroups, C2-4 alkynyl, halogen, cyano groups, acyl, nitryl or hydroxyl. The compound has high insecticidal activity for aphids, part of compound has the insecticidal activity for aphids equivalent tothat of a commercial insecticide dinotefuran, and the compound can be used for controlling lepidoptera pests, coleoptera pests, heteropteran pests, diptera pests, orthoptera pests and homoptera pests.

IRON COMPLEXING AGENT AND USES THEREOF IN THE TREATMENT AND PREVENTION OF COLORECTAL CANCER

A complex comprising a non-absorbable portion attached to an iron chelator moiety, a composition comprising the complex and the use of the complex in the treatment of colorectal cancer. In one embodiment the non-absorbable portion is a polymer such as a polysaccharide, including chitosan, chitin, cellulose or pectin. In one embodiment the iron chelator moiety comprises at least one functional group selected from catechol, hydroxamate or carboxylate, or any combination thereof.

Synthesis and characterization of related substances of deferasirox, an iron (Fe3+) chelating agent

Deferasirox is an orally active iron chelating agent, and during process development for deferasirox, we observed six related substances (impurities), namely deferasirox methyl ester, deferasirox salicylyl derivative, deferasirox ethyl ester, deferasirox methoxy carbonyl derivative, bis(salicyl)imide, and deferasirox-2-isomer. The present work describes the detection, origin, synthesis, and characterization of these related substances.

Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators

The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R1-R5are as defined in the description. The compounds have useful pharmaceutical properties and are particularly active as iron chelators. They can be used for the treatment of iron overload in warm-blooded animals.