201543-06-8Relevant academic research and scientific papers
Synthesis of chiral 3-substituted isoxazolidines
Farr, Roger N.
, p. 195 - 196 (1998)
The synthesis of chiral (>98% ee) 3-substituted isoxazolidines has been achieved. Glycidyl tosylate was utilized to establish the desired stereochemistry in a 'double grignard' reaction sequence. Mesylate displacement followed by acid-catalyzed cyclization allows the parent isoxazolidines to be obtained.
