Synthesis of chiral 3-substituted isoxazolidines

DOI: 10.1016/S0040-4039(97)10523-8

Source and publish data:

Tetrahedron Letters p. 195 - 196 (1998)

Update date:2022-08-05

Topics:: Authors:

Farr, Roger N.

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Article abstract of DOI:10.1016/S0040-4039(97)10523-8

The synthesis of chiral (>98% ee) 3-substituted isoxazolidines has been achieved. Glycidyl tosylate was utilized to establish the desired stereochemistry in a 'double grignard' reaction sequence. Mesylate displacement followed by acid-catalyzed cyclization allows the parent isoxazolidines to be obtained.

Full text of DOI:10.1016/S0040-4039(97)10523-8

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Article Doi

Synthesis of chiral 3-substituted isoxazolidines

DOI: 10.1016/S0040-4039(97)10523-8

Source and publish data:

Authors:

Article abstract of DOI:10.1016/S0040-4039(97)10523-8

Full text of DOI:10.1016/S0040-4039(97)10523-8

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