Tetrahedron Letters p. 195 - 196 (1998)
Update date:2022-08-05
Topics:
Farr, Roger N.
The synthesis of chiral (>98% ee) 3-substituted isoxazolidines has been achieved. Glycidyl tosylate was utilized to establish the desired stereochemistry in a 'double grignard' reaction sequence. Mesylate displacement followed by acid-catalyzed cyclization allows the parent isoxazolidines to be obtained.
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