201598-30-3

Upstream product

• 170656-31-2 6-(benzyloxy)hexan-1-ol methanesulfonate 
• 105-53-3 diethyl malonate 
• 71126-73-3 6-benzyloxyhexan-1-ol 
• 54247-27-7 1-bromo-6-benzyloxyhexane 
• 100-44-7 benzyl chloride 
• 629-11-8 1,6-hexanediol 
• 97510-97-9 (((6-iodohexyl)oxy)methyl)benzene 

Downstream Products

• 1025809-58-8 2-<6-(benzyloxy)hexyl>propane-1,3-diol 
• 207132-18-1 8-benzyloxy-1-octanoic acid 
• 1025840-23-6 2-<6-(benzyloxy)hexyl>propane-1,3-diol bis(4-methylbenzenesulfonate) 
• 1026470-41-6 toluene-4-sulfonic acid 8-benzyloxy-2-hydroxymethyl-octyl ester 
• 247062-82-4 (8-benzyloxy-2-{[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-methyl}-octyl)-(4-tert-butoxycarbonylamino-butyl)-carbamic acid tert-butyl ester 
• 247062-81-3 N¹-{2-[(4-amino-butylamino)-methyl]-8-benzyloxy-octyl}-butane-1,4-diamine 
• 247062-80-2 N,N'-bis-(4-amino-butyl)-2-(6-benzyloxy-hexyl)-malonamide 

Relevant academic research and scientific papers

Oxirane carboxylic acid derivative and its manufacturing method

PCT No. PCT/KR97/00132 Sec. 371 Date May 11, 1999 Sec. 102(e) Date May 11, 1999 PCT Filed Jul. 2, 1997 PCT Pub. No. WO98/00422 PCT Pub. Date Jan. 8, 1998This invention relates to a novel oxirane carboxylic acid derivative and thereof manufacturing method.

Synthesis of extremely simplified compounds possessing the key pharmacophore units of taxol, phenylisoserine and oxetane moieties

Straight chain compounds having a phenylisoserine unit and an oxetane ring at the α- and ω- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.

Method of inhibiting parasitic activity

A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

Synthesis and Properties of New Lipophilic Macrotricyclic Cylindrical Cryptands

Cylindrical cryptands 2a-c, in which two 1,7-dioxa-4,10-diazacyclododecane rings are connected by two equally substituted propylene bridges, have been obtained in appreciable yields by a ''one-pot'' synthesis.The assembling of the macrotricyclic structure is likely driven by the template effect of metal cations.These compounds, both as free receptors or as complexes, exist as cis and trans diastereoisomers, which do not interconvert and have been separated and characterized by X-ray analysis.The extraction constants (Ke) of cryptands 2 for alkali picrates under CHCl3/H2O and solid/liquid two-phase conditions have been measured by UV-vis spectrophotometry.The complexation behavior of cryptands 2 has been rationalized analyzing the preorganization of binding sites in the minimum energy conformations obtained by molecular mechanics calculations.Minimum energy conformations have been calculated also for the previously reported cryptands 1 and have been compared with those of 2.Results fit reasonably well with those of X-ray structures.