201669-72-9

Upstream product

• 250672-66-3 (1R,2R)-2-formyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane 
• 3465-72-3 urocanic Acid 
• 201669-68-3 (E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(1-trityl-1H-imidazol-4-yl)-propenone 
• 201669-67-2 (E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(1H-imidazol-4-yl)-propenone 
• 76-83-5 trityl chloride 
• 201669-70-7 ((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(1R,2R)-2-(1-trityl-1H-imidazol-4-yl)-cyclopropyl]-methanone 

Downstream Products

• 524696-02-4 (1R,2R)-2-azidocarbonyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane 
• 524696-04-6 (1S,2S)-2-azidocarbonyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane 
• 524696-10-4 (1S,2S)-2-(t-butyloxycarbonylamino)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane 
• 524696-09-1 (1R,2R)-2-(t-butyloxycarbonylamino)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane 

Relevant academic research and scientific papers

Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure

A series of cyclopropane-based conformationally restricted analogues of histamine, the "folded" cis-analogues, i.e., (1S,2R)-2-(aminomethyl)-1-(1H-imidazol-4-yl)cyclopropane (11), (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane (13), and their e

Diastereoselective synthesis of trans-2-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropanecarboxylic acids: Key intermediates for the preparation of potent and chiral histamine H3 receptor agents

Procedures for the preparation of both enantiomers of trans-2-(1-triphenylmethyl-1H-imidazol-4-yl)-cyclopropanecarboxylic acid are described. The key step in the synthesis is a 3:1 diastereoselective cyclopropanation of (5R)-trans-4-aza-10,10-dimethyl-3-t