201673-35-0

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 60110-67-0 5-iodo-α-2'-desoxyuridine 
• 104267-95-0 3',5'-di-O-(p-toluoyl)-5-iodo-α-2'-desoxyuridine 
• 31356-86-2 1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 201673-33-8 5-(propyn-1-yl)-α,2'-deoxyuridine 

Downstream Products

• 201673-37-2 1-[(2S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidine-2,4-dione 
• 201673-42-9 N-{1-[(2S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-5-prop-1-ynyl-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 201673-44-1 5'-O-(4,4'-dimethoxytrityl)-N-4-benzoyl-5-(propyn-1-yl)-α,2'-deoxycytidine 
• 201673-39-4 4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides

Incorporation of 5-propynylamino and 5-propynyl α-2′-deoxyuridine into α-oligonucleotides (α-ON) allows high-affinity targeting of complementary DNA for α-ON with anionic and neutral backbone but not for cationic α-ON, revealing clues on the role of the a

α-Oligodeoxynucleotides containing 5-propynyl analogs of α-deoxyuridine and α-deoxycytidine: Synthesis and base pairing properties

From propyne and 5-iodo-α,2-deoxyuridine, obtained by glycosylation, 5-propynyl-α,2'-deoxyuridine was synthesized following the procedure of Hobbs. One part was then transformed through displacement of its C4-triazolo derivative with ammonia into 5-propyn