20168-75-6

Basic information

• Product Name: Disulfide, 4-chlorophenyl 4-nitrophenyl
• CAS NO: 20168-75-6
• Molecular Formula: C12H8ClNO2S2
• Molecular Weight: 297.786
• Mol File: 20168-75-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Disulfide, 4-chlorophenyl 4-nitrophenyl(CAS DataBase Reference)
• NIST Chemistry Reference: Disulfide, 4-chlorophenyl 4-nitrophenyl(20168-75-6)
• EPA Substance Registry System: Disulfide, 4-chlorophenyl 4-nitrophenyl(20168-75-6)

Safety Data

• Hazardous Substances Data: 20168-75-6(Hazardous Substances Data)

Upstream product

• 21969-11-9 1-(4-chlorophenylthio)-4-nitrobenzene 
• 88683-47-0 2-((4-nitrophenyl)thio)isoindoline-1,3-dione 
• 106-54-7 p-Chlorothiophenol 
• 14204-31-0 2-(4-chlorophenylthio)isoindoline-1,3-dione 
• 1849-36-1 para-nitrobenzenethiol 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 937-32-6 4-nitrobenzenesulfenyl chloride 
• 58175-41-0 4-chloro-phenylmercury ⁽¹⁺⁾; thiophenolate 
• 106119-09-9 C₁₇H₁₇N₃O₄S 
• 60199-37-3 N-benzoyl p-nitrobenzenesulfenamide 
• 100-32-3 di(p-nitrophenyl) disulfide 

Downstream Products

• 116206-72-5 C₂₄H₁₈ClN₃O₆S₄ 

Relevant articles and documents

NFSI-catalyzed S[sbnd]S bond exchange reaction for the synthesis of unsymmetrical disulfides

The metal-free S[sbnd]S bond exchange reaction of symmetrical disulfides catalyzed by NFSI is described. This novel protocol provides a facile and efficient approach to accessing important unsymmetrical disulfides. Furthermore, this strategy could also be utilized in the late-stage functionalization of amino acids, drugs, and natural products. The broad substrate scope, good functional group tolerance and easy accessibility of catalyst indicate that this strategy affords a green and practical complementary method to various unsymmetrical disulfides.

Microwave-assisted synthesis of disulfides

A new microwave-assisted synthesis methodology for the preparation of substituted disulfide derivatives is presented. 4-Substituted sulfenimides were reacted with 4-substituted thiols under neat (to right doughy consistency) conditions in chloroform, with both microwave heating and conventional methods. The resulting 4-substituted disulfide derivatives were obtained at higher yields and in shorter reaction times with microwave heating. Their chemistry was confirmed by 1H-NMR, 13C-NMR, infrared (IR), and elemental analysis.

REACTION OF ARENESULFINIMIDIC ACID DERIVATIVES WITH THIOPHENOLS

The amides and esters of N-substituted arenesulfinimidic acids are reduced by the action of thiophenols primarily to N-substituted arenesulfenamides, while the thiophenols are oxidized to the corresponding derivatives of the arenesulfinic acids.