937-32-6

Basic information

• Product Name: 4-NITROBENZENESULFENYL CHLORIDE
• Synonyms: 4-NITROBENZENESULFENYL CHLORIDE;4-NITROBENZENESULFENYL CHLORIDE, TECH., CA. 95%;4-nitrophenyl hypochlorothioite;4-Nitrobenzenesulfenyl chloride technical grade, 95%
• CAS NO: 937-32-6
• Molecular Formula: C₆H₄ClNO₂S
• Molecular Weight: 189.62
• Product Categories: Sulfenyl Halides;Organic Building Blocks;Sulfur Compounds;Sulfenyl Halides;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds
• Mol File: 937-32-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 48-51 °C(lit.)
• Boiling Point: 125 °C0.1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /solid
• Density: 1.492 (estimate)
• Vapor Pressure: 1.37E-05mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-NITROBENZENESULFENYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROBENZENESULFENYL CHLORIDE(937-32-6)
• EPA Substance Registry System: 4-NITROBENZENESULFENYL CHLORIDE(937-32-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 937-32-6(Hazardous Substances Data)

Usage

Description

4-Nitrobenzenesulfenyl chloride is an organic chemical compound characterized by the presence of a nitro group attached to a benzene ring and a sulfonyl chloride group. It is known for its reactivity and is commonly utilized in various chemical reactions and processes.

Uses

Used in Organic Synthesis:
4-Nitrobenzenesulfenyl chloride is used as a reagent in organic synthesis for the formation of various chemical compounds. Its electrophilic nature allows it to participate in reactions such as cyclization, which is crucial for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Nitrobenzenesulfenyl chloride is used as an intermediate in the synthesis of certain drugs. Its ability to form stable intermediates makes it a valuable component in the development of new pharmaceutical agents.
Used in Chemical Research:
4-Nitrobenzenesulfenyl chloride is also used in chemical research as a tool to study the reactivity and properties of various organic compounds. Its unique structure and reactivity make it an interesting subject for research in the field of organic chemistry.
Used in n-Bu4NI-Induced Electrophilic Cyclization:
Specifically, 4-Nitrobenzenesulfenyl chloride has been employed in the n-Bu4NI-induced electrophilic cyclization of N,N-dimethyl-(2-phenylethynyl) aniline. This application showcases its utility in facilitating specific types of chemical reactions that are important for the synthesis of certain organic compounds.

InChI:InChI=1/C6H4ClNO2S/c7-11-6-3-1-5(2-4-6)8(9)10/h1-4H

Upstream product

• 15119-62-7 1-acetylsulfanyl-4-nitro-benzene 
• 128-09-6 N-chloro-succinimide 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 100-00-5 4-chlorobenzonitrile 
• 67-66-3 chloroform 
• 7782-50-5 chlorine 
• 7647-01-0 hydrogenchloride 
• 4837-33-6 o-nitrobenzenesulfenanilide 
• 60-29-7 diethyl ether 
• 1821-34-7 N-chlorobenzamide 
• 60199-37-3 N-benzoyl p-nitrobenzenesulfenamide 
• 49591-76-6 C₁₀H₁₃ClN₂O₂S 
• 1849-36-1 para-nitrobenzenethiol 

Downstream Products

• 60094-81-7 1-[(4-nitrophenyl)thio]piperidine 
• 533886-12-3 5-(4-nitro-phenylsulfanyl)-4-phenyl-thiazol-2-ylamine 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 1041-15-2 p-nitrophenyl p-nitrobenzenethiosulfonate 
• 94584-44-8 disulfidothiophosphoric acid O,O'-diethyl ester-S-S-(4-nitro-phenyl ester) 
• 861529-56-8 4-nitro-benzenesulfenic acid methylamide 
• 6140-33-6 1-((Z)-2-Chloro-2-phenyl-vinylsulfanyl)-4-nitro-benzene 
• 124480-49-5 O-ethyl-S-p-nitrophenyl-1-phenylethenylthiophosphonate 
• 72848-37-4 N-(4-bromophenyl)-S-(2-nitrophenyl)thiohydroxylamine 
• 33224-04-3 N-methyl-N-phenyl-2-nitrobenzenesulfenanilide 
• 125343-44-4 dicyanomethyl 4-nitrophenyl sulfide 
• 33121-25-4 N-(4-nitro-benzenesulfenyl)-glycine ethyl ester 
• 120549-14-6 N-(4-nitro-benzenesulfenyl)-acetimidic acid ethyl ester 
• 146310-45-4 5-amino-2-(4-nitro-phenylsulfanyl)-phenol 

Relevant articles and documents

Synthesis of 4-chalcogenyl pyrazoles via electrophilic chalcogenation/cyclization of α,β-alkynic hydrazones

A facile method for the synthesis of 4-chalcogenylated pyrazoles has been developed via electrophilic chalcogenation/cyclization of α,β-alkynic hydrazones. The cyclization of α,β-alkynic aldehyde hydrazones could be induced by using either sulfenyl chloride or the S-electrophiles generated in situ from the reaction of NCS and arythiol. The developed method was successfully applied to the synthesis of the sulfenyl analogue of celecoxib.

Tryptophan trimers and tetramers inhibit dengue and Zika virus replication by interfering with viral attachment processes

Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection in vitro. These compounds (AL family) have three or four peripheral tryptophan moieties directly linked to a central scaffold through their amino groups; thus, their carboxylic acid groups are free and exposed to the periphery. Structure-activity relationship (SAR) studies demonstrated that the presence of extra phenyl rings with substituents other than COOH at the N1 or C2 position of the indole side chain is a requisite for the antiviral activity against both viruses. The molecules showed potent antiviral activity, with low cytotoxicity, when evaluated on different cell lines. Moreover, they were active against laboratory and clinical strains of all four serotypes of dengue virus as well as a selected group of Zika virus strains. Additional mechanistic studies performed with the two most potent compounds (AL439 and AL440) demonstrated an interaction with the viral envelope glycoprotein (domain III) of dengue 2 virus, preventing virus attachment to the host cell membrane. Since no antiviral agent is approved at the moment against these two flaviviruses, further pharmacokinetic studies with these molecules are needed for their development as future therapeutic/prophylactic drugs.

Reactivity of the nitrogen-centered tryptophanyl radical in the catalysis by the radical SAM enzyme NosL

The radical SAM tryptophan (Trp) lyase NosL involved in nosiheptide biosynthesis catalyzes two parallel reactions, converting l-Trp to 3-methyl-2-indolic acid (MIA) and to dehydroglycine and 3-methylindole, respectively. The two parallel reactions diverge from a nitrogen-centered tryptophanyl radical intermediate. Here we report an investigation on the intrinsic reactivity of the tryptophanyl radical using a chemical model study and DFT calculations. The kinetics of the formation and fragmentation of this nitrogen-centered radical in NosL catalysis were also studied in detail. Our analysis explains the intriguing catalytic promiscuity of NosL and highlights the remarkable role this enzyme plays in achieving an energetically highly unfavorable transformation.