20169-46-4

Basic information

• Product Name: 2-Chloro-2'-hydroxybenzanilide
• Synonyms: 2-Chloro-2'-hydroxybenzanilide
• CAS NO: 20169-46-4
• Molecular Formula: C₁₃H₁₀ClNO₂
• Molecular Weight: 247.677
• Mol File: 20169-46-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 318.3°Cat760mmHg
• Flash Point: 146.3°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 0.000196mmHg at 25°C
• Refractive Index: 1.681
• CAS DataBase Reference: 2-Chloro-2'-hydroxybenzanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-2'-hydroxybenzanilide(20169-46-4)
• EPA Substance Registry System: 2-Chloro-2'-hydroxybenzanilide(20169-46-4)

Safety Data

• Hazardous Substances Data: 20169-46-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10ClNO2/c14-10-6-2-1-5-9(10)13(17)15-11-7-3-4-8-12(11)16/h1-8,16H,(H,15,17)

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 95-55-6 2-amino-phenol 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 3158-85-8 10H-dibenzo[b,f][1,4]oxazepin-11-one 
• 3164-09-8 2-(2-chlorophenyl)-1,3-benzoxazole 
• 135810-42-3 10-isopropyl-10H-dibenz[b,f][1,4]oxazepin-11-one 
• 135810-46-7 10-Allyl-10H-dibenzo[b,f][1,4]oxazepin-11-one 

Relevant articles and documents

Iron(III) Chloride Mediated para-Selective C-H Functionalization: Access to C5-Chloro and C5,C7-Dichloro/Dianisyl Substituted 2-Arylbenzoxazoles

Iron(III) chloride mediated para-selective C?H chlorination and subsequent annulation of 2-amidophenol to synthesize C5- and C5, C7-chlorinated benzoxazoles was developed. Further, the oxidative cross-dehydrogenative coupling of amidophenol with anisole b

Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones

Dibenzoxazepin-11(10H)-ones (III), pyridobenzoxazepin-6(5H)-ones (IV), and pyridobenzoxazepin-5(6H)-ones (V) were found to inhibit human immunodeficiency virus type 1 reverse transcriptase with IC50 values as 19 nM.A-ring substitution has a profound effect on activity, with appropriate substituents at the positions ortho and para to the lactam nitrogen providing dramatically enhanced potency.Substitution in the C-ring is generally neutral or detrimental to activity.Although a C-ring amino substituent at the position meta to the lactam carbonyl is generally beneficial to activity, it has essentially no effect when the A-ring is optimally substituted.Like the dipyridodiazepinone nevirapine, compounds III-V are specific for HIV-1 RT, exhibiting no inhibitory activity against HIV-2 RT or other virial reverse transcriptase enzymes.