201788-90-1 Usage
Uses
Used in Pharmaceutical Industry:
10-DEBC HYDROCHLORIDE is used as a research chemical for the development of cancer therapeutics. It targets the AKT pathway, which is often dysregulated in various types of cancer, leading to uncontrolled cell growth and resistance to apoptosis. By inhibiting this pathway, 10-DEBC HYDROCHLORIDE has the potential to suppress tumor growth and induce cell death in cancer cells.
Used in Cancer Research:
10-DEBC HYDROCHLORIDE is used as a tool compound in cancer research to study the role of the AKT pathway in tumorigenesis and to identify potential therapeutic targets for cancer treatment. It can be used in combination with other drugs, such as chloroquine, to enhance the efficacy and selectivity of tumor cell killing.
Used in Drug Development:
10-DEBC HYDROCHLORIDE is used in the development of novel drugs targeting the AKT pathway for the treatment of various cancers. It can be used as a lead compound to design and synthesize new molecules with improved potency, selectivity, and pharmacokinetic properties.
Used in Preclinical Studies:
10-DEBC HYDROCHLORIDE is used in preclinical studies to evaluate its antitumor activity, mechanism of action, and potential side effects. These studies are crucial for understanding the therapeutic potential of 10-DEBC HYDROCHLORIDE and for guiding its further development as a cancer therapeutic agent.
Biological Activity
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells.
Check Digit Verification of cas no
The CAS Registry Mumber 201788-90-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,7,8 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 201788-90:
(8*2)+(7*0)+(6*1)+(5*7)+(4*8)+(3*8)+(2*9)+(1*0)=131
131 % 10 = 1
So 201788-90-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
201788-90-1Relevant academic research and scientific papers
Synthesis and analysis of structural features of phenoxazine analogues needed to reverse vinblastine resistance in multidrug resistant (MDR) cancer cells
Eregowda,Kalpana,Hegde,Thimmaiah
, p. 243 - 259 (2007/10/03)
In an attempt to find clinically useful modulators of multidrug resistance (MDR), a series of twentyone 2-chloro-N10-substituted phenoxazines has been synthesized. The novel 2-chlorophenoxazine is prepared by the pyrolytic condensation of 2-bro
