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201848-59-1

4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 201848-59-1 Structure

  • Basic information

    1. Product Name: 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester
    2. Synonyms: 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester
    3. CAS NO:201848-59-1
    4. Molecular Formula:
    5. Molecular Weight: 358.232
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 201848-59-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester(201848-59-1)
    11. EPA Substance Registry System: 4-(2-bromo-2-methyl-propionyloxy)-3-isopropylamino-benzoic acid methyl ester(201848-59-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 201848-59-1(Hazardous Substances Data)

201848-59-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 201848-59-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,8,4 and 8 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 201848-59:
(8*2)+(7*0)+(6*1)+(5*8)+(4*4)+(3*8)+(2*5)+(1*9)=121
121 % 10 = 1
So 201848-59-1 is a valid CAS Registry Number.

201848-59-1Relevant articles and documents

An acid-catalyzed O,N-acyl migration and application to the synthesis of N-(4-isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6- carbonyl) guanidine methanesulfonate (KB-R9032), a novel Na/H exchange inhibitor

Yamamoto, Takeshi,Hori, Manabu,Watanabe, Ikuo,Tsutsui, Hisayoshi,Ikeda, Shoji,Ohtaka, Hiroshi

, p. 22 - 27 (2007/10/03)

In the search for a practical synthesis of N-(4-isopropyl-2,2-dimethyl- 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl)guanidine methanesulfonate (KB-R9032), a potent Na/H exchange inhibitor, the acylation of methyl 4- hydroxy-3-isopropylaminobenzoate 6a with 2-bromoisobutyryl bromide was carried out in order to prepare an N-acyl derivative, 8a. However, an O-acyl derivative 7a was obtained selectively. Acylations of derivatives of 6a were examined. The results revealed that the O-acylation occurred because of the steric repulsion between the N-isopropyl moiety and the bulky acyl bromide. Then, we investigated the O,N-acyl migration of 7a. We found that the migration was catalyzed by carboxylic acid and that 8a was precipitated from a diisopropyl ether solution in good yield. Treatment of 8a with potassium carbonate and subsequent guanidine gave the synthetic intermediate for KB- R9032 in high yield.

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