20196-21-8

Basic information

• Product Name: thiomorpholin-3-one
• Synonyms: thiomorpholin-3-one;THIOMORPHOLINONE;3-Thiomorpholinone
• CAS NO: 20196-21-8
• Molecular Formula: C₄H₇NOS
• Molecular Weight: 117.16948
• EINECS: 243-581-8
• Mol File: 20196-21-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 87-89 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 349.3 °C at 760 mmHg
• Flash Point: 165 °C
• Appearance: /
• Density: 1.189 g/cm³
• Vapor Pressure: 4.76E-05mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• PKA: 14.19±0.20(Predicted)
• CAS DataBase Reference: thiomorpholin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: thiomorpholin-3-one(20196-21-8)
• EPA Substance Registry System: thiomorpholin-3-one(20196-21-8)

Safety Data

• Hazardous Substances Data: 20196-21-8(Hazardous Substances Data)

Usage

General Description

Thiomorpholin-3-one, also known as 3-thiomorpholinone or 3-sulfanylmorpholin-4-one, is a chemical compound used in organic synthesis. It has a molecular formula of C4H7NO2S, and is categorized under the class of organoheterocyclic compounds known as morpholines, which contain a saturated or unsaturated aliphatic six-member ring with four carbon atoms and one nitrogen and oxygen each. Thiomorpholin-3-one is vital in the chemical industry as it serves as a crucial building block or reagent in creating more complex chemical structures, often used in the production of pharmaceuticals, agrochemicals, and functional materials.

InChI:InChI=1/C4H7NOS/c6-4-3-7-2-1-5-4/h1-3H2,(H,5,6)

Upstream product

• 151-56-4 ethyleneimine 
• 623-51-8 ethyl 2-sulfanylacetate 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 
• 60-23-1 Cysteamine 
• 497-25-6 dimethylenecyclourethane 
• 96125-49-4 methyl trans-3-(4-methoxyphenyl)glycidate 

Downstream Products

• 123-90-0 Thiomorpholin 
• 65922-77-2 (2,6-diethyl-phenyl)-(5,6-dihydro-2H-[1,4]thiazin-3-yl)-amine 
• 65922-80-7 (5,6-dihydro-2H-[1,4]thiazin-3-yl)-(2-ethyl-6-methyl-phenyl)-amine 
• 65922-76-1 4-(5,6-dihydro-2H-[1,4]thiazin-3-ylamino)-benzenesulfonamide 
• 65922-82-9 (5,6-dihydro-2H-[1,4]thiazin-3-yl)-(3,4,5-trimethoxy-phenyl)-amine 
• 65922-79-4 (5,6-dihydro-2H-[1,4]thiazin-3-yl)-o-tolyl-amine 
• 67374-14-5 4-(N-methyl-anilinomethyl)-thiomorpholin-3-one 

Relevant articles and documents

Realizing the Trifunctional Potential of Alkyl 4-Chloro-2-diazo-3-oxobutanoates: Convenient Assembly of 6,7-Dihydro-4 H-[1,2,3]triazolo[5,1-c][1,4]thiazine Core

The first example of exploiting the trifunctional character of alkyl 4-chloro-2-diazo-3-oxobutanoates in the reactions with vicinal N, S-bis-nucleophiles leading to the formation of bicyclic 6,7-dihydro-4 H-[1,2,3]triazolo[5,1-c][1,4]thiazines is presente

Construction of tertiary chiral centers by Pd-catalyzed asymmetric allylic alkylation of prochiral enolate equivalents

Abstract The palladium-catalyzed decarboxylative allylic alkylation of enol carbonates derived from lactams and ketones is described. Employing these substrates with an electronically tuned Pd catalyst system trisubstituted chiral centers are produced. These stereocenters have been previously challenging to achieve using Pd complex/chiral P-N ligand systems.

Base-promoted aminoethylation of thiols with 2-oxazolidinones: A simple synthesis of 2-aminoethyl sulfides

A simple synthesis of 2-aminoethyl sulfides using a base-promoted reaction of 2-oxazolidinones with thiols is described. An application of this method to the synthesis of chiral 2-aminoethyl sulfides and sulfur-containing heterocyclic compounds is also presented.