202062-71-3

Upstream product

• 77-76-9 2,2-dimethoxy-propane 
• 202062-70-2 2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester 
• 3282-30-2 pivaloyl chloride 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 202062-65-5 (1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol 
• 202062-63-3 (1S,2S,4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-1-hydroxymethyl-5-(4-methoxy-benzyloxymethyl)-5-methyl-cyclohexane-1,2-diol 
• 202062-62-2 (1S,3R,4R,5S)-5-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxymethyl)-4-methyl-2-methylene-cyclohexanol 
• 202062-61-1 [(1R,2R,3S)-3-Benzyloxy-2-(4-methoxy-benzyloxymethyl)-2-methyl-6-methylene-cyclohexylmethoxy]-tert-butyl-diphenyl-silane 
• 202062-66-6 (1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol 
• 202062-59-7 (Z)-5-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-3-methyl-oxiranyl]-3-trimethylsilanylmethyl-pent-2-enoic acid methyl ester 
• 202062-60-0 (1R,2R,3S)-3-Hydroxy-2-(4-methoxy-benzyloxymethyl)-2-methyl-6-methylene-cyclohexanecarboxylic acid methyl ester 

Relevant academic research and scientific papers

A concise synthetic approach to optically active taxol C-ring fragment

A concise synthetic approach to an optically active taxol C-ring fragment starting from a readily available compound is described. Lewis acid promoted-cyclization of optically active epoxy trimethylsilane 7 affords the key intermediate 8 in 69% yield (at 91% conversion). Further transformation of 8 to our taxol C-ring fragment is successfully achieved in a stereoselective manner.