2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester
CAS No.:202062-71-3
Molecular Formula:C₄₉H₆₄O₈Si
Molecular Weight:809.128
Hs Code.:

2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

Synonyms:2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 77-76-9
2,2-dimethoxy-propane

: 202062-70-2
2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

: 202062-71-3
2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 3282-30-2
pivaloyl chloride

: 202062-71-3
2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / DMAP / CH₂Cl₂ / 0 deg C up to RT

2: 96 percent / CSA / CH₂Cl₂ / Ambient temperature

With dmap; camphor-10-sulfonic acid; In dichloromethane;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 202062-71-3
2,2-Dimethyl-propionic acid (3aS,4R,5R,6S,7aS)-6-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2,5-trimethyl-tetrahydro-benzo[1,3]dioxol-3a-ylmethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

2: 69 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -60 °C

3: LiAlH₄ / diethyl ether / 1 h / 0 deg C up to RT

4: 97 percent / imidazole / CH₂Cl₂ / 0 deg C up to RT

5: 99 percent / nBu₄NI, KH / tetrahydrofuran / Ambient temperature

6: 84 percent / SeO₂, 70percent TBHP, salicylic acid / CH₂Cl₂ / 12 h / Ambient temperature

7: 82 percent / OsO₄, Me₃NO / acetone; H₂O / 36 h / Ambient temperature

8: 97 percent / DMAP / CH₂Cl₂ / 0 deg C up to RT

9: 96 percent / CSA / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; tert.-butylhydroperoxide; dmap; osmium(VIII) oxide; lithium aluminium tetrahydride; selenium(IV) oxide; trimethylamine-N-oxide; 4 A molecular sieve; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; potassium hydride; salicylic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(97)10554-8