202134-44-9

Upstream product

• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 202134-42-7 (2S)-benzyl 1-hydroxy-3-phenylpropan-2-yl(methyl)carbamate 
• 24164-73-6 methyl (S)-2-(benzyloxycarbonyl-methyl-amino)-3-phenylpropionate 

Downstream Products

• 202134-46-1 ((S)-1-Benzyl-allyl)-methyl-carbamic acid benzyl ester 
• 716371-65-2 benzyl (2S,3R)-3-((3R,4S)-4-(N-((S)-2-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-tert-butyldimethylsilyloxy-5-phenylpentanoyloxy)-2-methyldecanoate 
• 716371-58-3 (1R)-2-endo-[(3R,4S)-4-(N-((2S)-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-tert-butyldimethylsilyloxy-5-phenylpentanoyl]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol 
• 716371-66-3 (2S,3R)-3-((3R,4S)-3-tert-butyldimethylsilyloxy-4-(N-((S)-2-hydroxy-3-methylbutanoyl)-N-methylamino)-5-phenylpentanoyloxy)-2-methyldecanoate 
• 716371-56-1 (1R)-2-endo-[(3R,4S)-4-(N-((S)-2-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-hydroxy-5-phenylpentanoyl]-2-exo-trimethylsilyloxy-1,7,7-trimethylbicyclo[2.2.1]heptane 
• 716371-57-2 (1R)-2-endo-[(3R,4S)-4-(N-((2S)-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-hydroxy-5-phenylpentanoyl]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol 
• 716371-55-0 (1R)-2-endo-[(3R,4S)-3-hydroxy-4-(N-methylamino)-5-phenylpentanoyl]-2-exo-trimethylsilyloxy-1,7,7-trimethylbicyclo[2.2.1]heptane 
• 716371-59-4 (3R,4S)-4-(N-((S)-2-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-tert-butyldimethylsilyloxy-5-phenylpentanoic acid 
• 173204-79-0 (2S,5S,6R,10R,11S)-5-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-10-heptyl-2-isopropyl-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione 
• 159542-04-8 (-)-hapalosin 
• 716371-47-0 (1R)-2-endo-[(3R,4S)-4-(N-benzyloxycarbonyl-N-methylamino)-3-hydroxy-5-phenylpentanoyl]-2-exo-trimethylsilyloxy-1,7,7-trimethylbicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

A practical total synthesis of hapalosin, a 12-membered cyclic depsipeptide with multidrug resistance-reversing activity, by employing improved segment coupling and macrolactonization

A practical total synthesis of hapalosin, a compound with multidrug resistance-reversing activity, has been carried out using an unprecedented macrolactonization strategy. One of the features of the new approach is the straightforward and fully stereocont

The first asymmetric synthesis of (1R,1′S)-1-[1′-(benzyloxycarbonyl-methylamino)-2′-phenylethyl] oxirane: A promising building block for the synthesis of peptide mimics

The threo N-methyl oxirane 5 was prepared from (S)-N-methyl phenylalanine by bromoketone reduction or by epoxidation routes. The unexpected stereochemical result of the reduction of bromoketone 7 leading to the threo isomer is discussed.