716371-57-2

Upstream product

• 716371-56-1 (1R)-2-endo-[(3R,4S)-4-(N-((S)-2-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-hydroxy-5-phenylpentanoyl]-2-exo-trimethylsilyloxy-1,7,7-trimethylbicyclo[2.2.1]heptane 
• 110298-78-7 methyl (S)-2-(benzyloxy)-3-methylbutanoate 
• 110720-19-9 (2S)-2-(benzyloxy)-3-methylbutanoyl chloride 
• 716371-47-0 (1R)-2-endo-[(3R,4S)-4-(N-benzyloxycarbonyl-N-methylamino)-3-hydroxy-5-phenylpentanoyl]-2-exo-trimethylsilyloxy-1,7,7-trimethylbicyclo[2.2.1]heptane 
• 716371-55-0 (1R)-2-endo-[(3R,4S)-3-hydroxy-4-(N-methylamino)-5-phenylpentanoyl]-2-exo-trimethylsilyloxy-1,7,7-trimethylbicyclo[2.2.1]heptane 
• 24164-73-6 methyl (S)-2-(benzyloxycarbonyl-methyl-amino)-3-phenylpropionate 
• 202134-44-9 (S)-benzyl methyl(1-oxo-3-phenylpropan-2-yl)carbamate 
• 391871-69-5 (S)-2-(benzyloxy)-3-methylbutanoic acid 

Downstream Products

• 716371-58-3 (1R)-2-endo-[(3R,4S)-4-(N-((2S)-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-tert-butyldimethylsilyloxy-5-phenylpentanoyl]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol 
• 159542-04-8 (-)-hapalosin 
• 173204-79-0 (2S,5S,6R,10R,11S)-5-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-10-heptyl-2-isopropyl-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione 
• 716371-59-4 (3R,4S)-4-(N-((S)-2-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-tert-butyldimethylsilyloxy-5-phenylpentanoic acid 
• 716371-66-3 (2S,3R)-3-((3R,4S)-3-tert-butyldimethylsilyloxy-4-(N-((S)-2-hydroxy-3-methylbutanoyl)-N-methylamino)-5-phenylpentanoyloxy)-2-methyldecanoate 
• 716371-65-2 benzyl (2S,3R)-3-((3R,4S)-4-(N-((S)-2-benzyloxy-3-methylbutanoyl)-N-methylamino)-3-tert-butyldimethylsilyloxy-5-phenylpentanoyloxy)-2-methyldecanoate 

Relevant academic research and scientific papers

A practical total synthesis of hapalosin, a 12-membered cyclic depsipeptide with multidrug resistance-reversing activity, by employing improved segment coupling and macrolactonization

A practical total synthesis of hapalosin, a compound with multidrug resistance-reversing activity, has been carried out using an unprecedented macrolactonization strategy. One of the features of the new approach is the straightforward and fully stereocont